I am using Jaws 12 with XP professional and they are good together. A few years ago I got shafted though when I was purchasing a new system and the man who was building the system for me talked me into accepting XP professional rather than home. That meant I had to upgrade my current Jaws license to accept professional and it cost me about two hundred dollars. I went along with this, though somewhat reluctantly because the computer dealer I was working with had given me a very good deal on the system I wanted. I like Jaws 12; and I find XP professional a little more secure in some ways than the home version. So I guess your big decider will be whether you want to spend the money. Hope you find satisfaction. Lois Goodine.