I have seen this issue when the Office File Validation update has been installed. Thanks Webster From: thin-bounce@xxxxxxxxxxxxx [mailto:thin-bounce@xxxxxxxxxxxxx] On Behalf Of Angela Smith Sent: Friday, April 19, 2013 8:03 AM To: thin@xxxxxxxxxxxxx Subject: [THIN] Off topic - Excel 2010 issues on Citrix Hi I recently installed Office 2010 on XenApp 4.5 (running on Windows 2003) for our finance team. I'm having quite a few issues where Excel intermittently has the following issues: - Locks up when trying to open or save a document - Intermittently gets "Microsoft Excel is waiting for another application to complete an OLE action" - Excel isn't releasing the file from File Server. Windows 2003 open files shows user has file open but from a client perspective on citrix nothing is open. - Very slow to save (30 minutes) Ive tried the following: - Run Excel in Safe mode - no difference. - Published Excel on another server with no Addins - no difference - Server resources are fine. I have 1 user running on a 2 x Quad core physical server with 24Gb RAM and these issues occur - For OLE issue, I have checked and unchecked "Ignore other applications that use Dynamic Data Exchange (DDE)" - no difference The files are financial and have lots of macros in them. Are there any best practice guides in relation to configuring Excel on Citrix? Thanks Ang