Finally, please do a search for "Apo A-I Milano". My search produced 319,000 hits, the first on my list being http://www.medicalnewstoday.com/articles/33816.php. Other sources I've seen indicate that all who carry this gene are descended from a single marriage about 400 years ago. If you do not subscribe to the concept of evolution, how would you explain this phenomenon? Paul D What has geaneology to do with evolution? The church has always recognised inbreeding as a danger, and forbids it .. Perhaps it is proof of devolution? Phil.