As the title suggests we are running AppV 5.0 SP2 with a recently installed http://support.microsoft.com/kb/2934349 I have a XenApp 6.5 PVS image in read only mode and when launching AppV apps I seem to be able to launch some apps first time only.Doesnt matter if im admin, or normal userDoesnt matter if im using RDP or ICADoesnt matter if I clear my profile - from then on the apps are dead, for all users.Fix so far is reboot... which is AWESOME! We are using the Appv 5 publishing server with Shared content mode (support staff etc need to be able to deploy apps to servers, and dont want packages baked into the image if at all possible) Example:If I log on, launch an AppV app Winzip 18, It loads first time, then on subsequent retries does literally nothingFrom then on the launching of other AppV apps break SQL Management consoleYet one AppV application, AGS Remote Desktop, continues to work without issue - launches everytime!The logging of AppV 5 client is garbage, and there is literally nothing in the event logs either, all we see is the operation event log info of:A request for the file C:\ProgramData\App-V\12160C7F-CB16-4D45-BE71-A36E3BBD15A2\37568102-90C5-4115-8382-28A009AF1C5F\Root\en-US\winzip64.exe.mui from process 0x2144 is being processed as an alternate user S-1-5-21-162393699-21082718-2283726478-38935. We do little in preparing the PVS image before read only mode other than removing all the packages from the server before shutdownGet-AppvClientPackage -All | Remove-AppVClientPackage My Questions:Has anyone seen this behaviour?Are there further steps to prepare the PVS image for running AppV Apps in infrastructure mode? i.e (an AppV refresh script at the server startup?) Thank you in advance,Beers on me if you can get this working for us!! :)James