Keith, before any design a complete set of specifications is needed, otherwise the circuit may be under or over designed. For your 1 uA signal the basic specs are: - Accuracy - voltage on the 1 uA node - measurement bandwidth - maximum temperature From these two specs you can derive: - maximum allowable leakage current of amplifiers and other components - maximum PCB leakage current - thermal and 1/f noise of components This information will drive the topology, the board material, guard traces (if any), driving guard traces, board material, stack-up, component selection, and so on. The *Keithley Low Level Measurements Handbook* is a must read for this type of design. http://www.keithley.com/promo/wb/1401 Dave Cuthbert NARTE Certified EMC Engineer, consultant on EMC, every thing analog, power, instrumentation, Rubium Technology LLC On Mon, Feb 3, 2014 at 5:46 PM, keithK EPD <epd2001usa@xxxxxxxxxxx> wrote: > I am using a mixed (rigid and flex) board (6 layers) for sense analog > signal around the order of 1uA (a current source). I have multible > sensors on this board .... after the sensors , the signal travels through > a 6" section of flex (now 3 layers) , and finally goes to a connector > away from the sensors. > > the questions are: what would be the best way to preserve the most > signal (x-talk) , interference, etc.... > Should the signals be sandwiched between copper ... > all signals are analog in nature..... no digital levels anywhere. > > keith kowal > keith@xxxxxxxxxxxxxxxxxxx > > any rules of thumb and why would be helpful > > > > ------------------------------------------------------------------ > To unsubscribe from si-list: > si-list-request@xxxxxxxxxxxxx with 'unsubscribe' in the Subject field > > or to administer your membership from a web page, go to: > //www.freelists.org/webpage/si-list > > For help: > si-list-request@xxxxxxxxxxxxx with 'help' in the Subject field > > > List forum is accessible at: > http://tech.groups.yahoo.com/group/si-list > > List archives are viewable at: > //www.freelists.org/archives/si-list > > Old (prior to June 6, 2001) list archives are viewable at: > http://www.qsl.net/wb6tpu > > > ------------------------------------------------------------------ To unsubscribe from si-list: si-list-request@xxxxxxxxxxxxx with 'unsubscribe' in the Subject field or to administer your membership from a web page, go to: //www.freelists.org/webpage/si-list For help: si-list-request@xxxxxxxxxxxxx with 'help' in the Subject field List forum is accessible at: http://tech.groups.yahoo.com/group/si-list List archives are viewable at: //www.freelists.org/archives/si-list Old (prior to June 6, 2001) list archives are viewable at: http://www.qsl.net/wb6tpu