[optimal] Re: 10% vs 25% Fluorescein

  • From: Alan Frohlichstein <alanfroh@xxxxxxxxx>
  • To: optimal@xxxxxxxxxxxxx
  • Date: Fri, 10 Mar 2017 10:45:35 -0600

Also keep the room on the cool side. I see nausea mostly on hot summer days when the AC is ineffective. I have almost none in the winter in Chicago.

Alan


On 3/10/2017 10:40 AM, lguerette@xxxxxxxxxxxxxxxxx wrote:


I agree that a true allergic reaction is going to happen no matter how much is given - maybe a lesser amount of hives ..., but it will still occur.

I find that the unfortunate side effects - nausea and vomiting - occur more when the patient is stressed/anxious about having the test done than by rate of injection. I try to calm them by talking with them through the injection, focusing on slow breathing to get their mind off what is going on.

As for comfort, once I have the focus in and set, I lower the illumination down significantly and that helps patient comfort. Nothing you can do about the flash - you need what you need to get good photos.

It is not worth any legal hassle having single dose vials used for multiple patients.

I've been taking FA photos for 15~16 years and fortunately never had anything more than seizures as the most severe.

Lori

Lori Guerette, CRA COA OCT-C

justhitanykey@xxxxxxxxxxx <mailto:justhitanykey@xxxxxxxxxxx>

-----Original Message-----
From: "George Henry, CRA, PBT" <ghenry@xxxxxxxxxxxxxx>
Sent: Friday, March 10, 2017 11:13am
To: optimal@xxxxxxxxxxxxx
Subject: [optimal] Re: 10% vs 25% Fluorescein

I, too, was going to comment on administering multiple doses from a single-dose vial. There have been some very

large fines and court settlements levied against doctors, clinics, and hospitals for doing that.

Absolutely NOT worth the risk.

George E. Henry, CRA, PBT (ASCP)

Wheaton Eye Clinic, Ltd.

2015 N. Main St

.

Wheaton, IL  60187

630.588.3615

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*From:*optimal-bounce@xxxxxxxxxxxxx [mailto:optimal-bounce@xxxxxxxxxxxxx] *On Behalf Of *Darrin Landry
*Sent:* Friday, March 10, 2017 9:20 AM
*To:* optimal@xxxxxxxxxxxxx
*Subject:* [optimal] Re: 10% vs 25% Fluorescein

With all due respect, I disagree with your logic. The rate of injection or amount of dye has nothing to do with adverse reactions to NaFl. If you give someone a slow injection, it will NOT prevent an allergic reaction (urticarial, cardiac arrest, death). If they are truly allergic to NaFl, reducing the amount given will not prevent a reaction.

In my 30 years experience, rate of injection also does not affect rate of vomiting either. I consistently inject at a rate of 1 cc per second, and have less than a 5% nausea/vomiting rate.

Also, NaFl is supplied as a SINGLE dose, not multiple dose.

Just my 2 cents

Darrin

**Darrin A Landry, CRA, OCT-C**

Ophthalmic Consultant

Bryson Taylor, Inc.

207-838-0961

www.brysontaylor.com <mailto:Darrin@xxxxxxxxxxxxxxxx>

------------------------------------------------------------------------

*From*: "Hector Mendez Caratini" <dmarc-noreply@xxxxxxxxxxxxx>
*Sent*: Friday, March 10, 2017 10:05 AM
*To*: "optimal@xxxxxxxxxxxxx" <optimal@xxxxxxxxxxxxx>
*Subject*: [optimal] Re: 10% vs 25% Fluorescein

Dear Coy and fellow ophthalmic photographers:

I would like to address a new safety concern topic:

It is not comfortable for the patient to rapidly inject (in less than 2 to 3 seconds) a bolus of 5cc 10% fluorescein dye and have him /or her vomit on you past the 30 seconds mark. It happens too frequently. More than you would like it to happen.

With the newer acquisition equipment (and old ones too, such as Topcon TRC 50’s), which are much more sensitive, I have been using the following technique.

To reduce the possibilities of adverse reactions (nausea, vomiting, urticaria, cardiac arrest and even death!), what I have been doing is injecting half the dose that comes inside the vial (it doesn’t matter if it is 10% or 25%, light or dark). It has worked very well for me. With practically NO allergic reactions a year, versus a lot monthly ones. You still can get an excellent Early Phase and Mid Phase fluorescein transit. Where you can easily identify the leaking pathology. Sometimes, the Late Phase (past seven minutes) images look a bit washed out. But, if you’re taking into consideration patient comfort and safety, it’s very well worth the dose.

Another positive side to this equation is that you’re reducing the monetary costs of the study. That is one vial for two patients. It is nice to obtain high quality exhibition grade images. But, please remember that patient safety should always be our main concern. Put yourself (or your dear family member) inside the patient’s shoes.

Hector Mendez Caratini, CRA

Puerto Rico


On Friday, March 10, 2017 9:47 AM, "Egnatz, Thomas" <tegnatz@xxxxxxxxx> wrote:

I am posting this for Coy. Sorry about the delay, I have been off Optimal for a month (new computer).

Tom

*From:*Cobb, Coy, VHACIN
*Sent:* Thursday, February 16, 2017 9:22 AM
*To:* 'optimal@xxxxxxxxxxxxx'
*Subject:* 10% vs 25% Fluorescein

   Morning all

Would anyone know of any studies comparing 5cc’s of 10%, verses 3 cc’s of 25% fluorescein ?

Specifically, I’m looking for anything that addresses adverse reactions.

Coy Cobb COT CRA



--
Alan Frohlichstein
5633 Crain Street
Morton Grove, IL 60053
847-965-7555

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