Dear Colleagues, Please see below for the latest upcoming events from CAAT. You can see a web version of the newsletter here: http://us4.campaign-archive2.com/?u=066d5d7abe2de2d5e04d214bf&id=71fccd3c68&e=4c7d58c42f Kristie Sullivan Secretary, ASCCT www.ascctox.org<http://www.ascctox.org> Begin forwarded message: From: Center for Alternatives to Animal Testing (CAAT) <caat@xxxxxxxxx<mailto:caat@xxxxxxxxx>> Subject: CAATwalk: News and Updates Date: February 6, 2013 12:56:20 PM PST To: Reply-To: Center for Alternatives to Animal Testing (CAAT) <caat@xxxxxxxxx<mailto:caat@xxxxxxxxx>> Updates from the Center for Alternatives to Animal Testing (CAAT) Email not displaying correctly? View it in your browser<http://us4.campaign-archive2.com/?u=066d5d7abe2de2d5e04d214bf&id=71fccd3c68&e=4c7d58c42f>. [http://gallery.mailchimp.com/066d5d7abe2de2d5e04d214bf/images/caatlogo.2.jpg]<http://jhsph.us4.list-manage1.com/track/click?u=066d5d7abe2de2d5e04d214bf&id=53e5e82ff9&e=4c7d58c42f> [http://gallery.mailchimp.com/27aac8a65e64c994c4416d6b8/images/twitter_24x24_p50.png] <http://jhsph.us4.list-manage1.com/track/click?u=066d5d7abe2de2d5e04d214bf&id=39d6bcb80c&e=4c7d58c42f> [http://gallery.mailchimp.com/27aac8a65e64c994c4416d6b8/images/facebook_24x24_p50.png] <http://jhsph.us4.list-manage.com/track/click?u=066d5d7abe2de2d5e04d214bf&id=d485ed0dc2&e=4c7d58c42f> CAATwalk February 6, 2013 February brings with it this year's call for proposals for CAAT's 2014-2015 grants, along with announcements of several important meetings. If you plan to attend, please be sure to add them to your calendar and make travel arrangements soon. And as always, feel free to forward this newsletter to your colleagues. Satellite Meeting at Society of Toxicology (SOT): Updates on 21st Century Toxicology Activities and Related Efforts Thursday, March 14, 2013 (Immediately after SOT ends) 12:30pm - 4pm San Antonio, Texas Grand Hyatt Presidio Room Presented by CAAT This meeting will provide a forum for interested stakeholders to update each other on efforts to advance pathway-based approaches to toxicology, as exemplified by the 2007 National Research Council report on “Toxicity Testing in the 21st Century” (“TT21C”). The meeting also will address efforts to promote the use of systematic reviews and related evidence-based approaches in toxicology, with an emphasis on their relevance to TT21C. Full SOT 2013 Calendar<http://jhsph.us4.list-manage1.com/track/click?u=066d5d7abe2de2d5e04d214bf&id=92bd3b8ea9&e=4c7d58c42f> (PDF) Program 12:30 Box lunch and Welcome, Thomas Hartung (Johns Hopkins University) 13:00 Invited Presentations (10 minutes each plus 5 minutes for discussion) * David Dix (US Environmental Protection Agency) – ToxCast Update * Raymond Tice (US National Institute of Environmental Health Science) – Tox21 Update * Russell Thomas (Hamner Institutes for Biomedical Sciences) – Hamner TT21C-related Activity Update * Thomas Hartung (Johns Hopkins) – The Center for Alternatives to Animal Testing’s TT21C-related Activity Update * Richard Judson (US EPA) – Validation of High-throughput Assays * Martin Stephens (Johns Hopkins) – Evidence-based Toxicology Update 14:30 Open microphone for additional presentations and discussion 16:00 Adjourn Questions? Please contact Marilyn Principe<http://jhsph.us4.list-manage.com/track/click?u=066d5d7abe2de2d5e04d214bf&id=46782b7e8f&e=4c7d58c42f>. ________________________________ EU Science: Global Challenges and Global Cooperation March 4-8, 2013 European Parliament, Brussels Details and Registration:http://www.globalsciencecollaboration.org<http://jhsph.us4.list-manage.com/track/click?u=066d5d7abe2de2d5e04d214bf&id=a83cf041fe&e=4c7d58c42f> Downloadable Flyer<http://jhsph.us4.list-manage.com/track/click?u=066d5d7abe2de2d5e04d214bf&id=ba615723a5&e=4c7d58c42f> (PDF) March 7th: New Regulatory Science in Systems Toxicology UPDATE ON THE KNOWLEDGE or PARADIGM SHIFT? Panel Discussion and Audience Questions * Thomas Hartung- Director, Center for Alternatives to Animal Testing (CAAT) * Emily McIvor– HSI * Donald Prater– FDA * Adrianno Henney– VIRTUAL LIVER * Rex Fitzgerald– SCAHT * Robert Barouki – INSERM * Francois Busquet– CAAT EUROPE– as MODERATOR Worldwide Implementation of the 3Rs in Regulatory Toxicology: What are the Leadership Challenges and Opportunities? Panel Discussion and Presentations * 3Rs Implementation in North America Paul Locke- Policy Program Director, Center for Alternatives to Animal Testing (CAAT) * 3Rs Implementation in Latin America Octavio Presgrave- BraCVAM * 3Rs Implementation in the EU Björn Hansen- EC * 3Rs Implementation in Japan, India, China, and Korea (Pacific Basin) Richard Fosse- GSK * 3Rs Implementation in Australia Brett Lidbury- Australian National University * Final Presentation: 3Rs Wrap-up and Summary What We Have Learned Today on the State of the Implementation of the 3Rs Joyce Tischler– Animal Legal Defense Fund ________________________________ Workshop: Lessons Learned, Challenges, and Opportunities: The US Endocrine Disruptor Screening Program April 23-24, 2013, Research Triangle Park, NC This workshop brings together multiple stakeholders including CAAT as co-organizer in an open forum to review and discuss the challenges and lessons learned from the initial experiences with Tier 1 screening assays. This open meeting, with all stakeholders—including Federal Regulatory Agencies, NGOs, industry, contract laboratory scientists, and academic researchers—is critical, and timely, to utilize the collective experience for potential improvements in Tier 1 assays and to further advance endocrine disruption assessment. All stakeholders and interested parties are invited to participate. Information and Registration: http://www.tera.org/peer/edsp<http://jhsph.us4.list-manage.com/track/click?u=066d5d7abe2de2d5e04d214bf&id=91021e817a&e=4c7d58c42f> ________________________________ Clinical Trial and Error: Beauty and the Beast February 15, 2013, Boston, MA 3-4:30pm Hynes Convention Center, Room 309 At the AAAS 2013 Annual Meeting Independent clinical trials are fundamental to improving the results, safety, and cost-effectiveness of health care. Because of costs, the scope of these trials is often limited to new products. Important clinical interventions, surgery, physiotherapy, and rehabilitation are of less interest to commercial sponsors seeking primarily drug and device authorization. Whereas investigator-driven studies now find support in the United States and European Union, they cannot match the resources available for commercial clinical trials. Public and charitable funding typically backs health care–orientated trials independently of manufacturers, but is often much smaller in size. Results matter. When we do get such new evidence, it allows us to look back: how good was the preclinical research to start with? While evidence-based medicine is the health care imperative of the 21st century, it remains difficult to generate the evidence base for pressing public health challenges. This session unites key stages and world authorities in the clinical trials process to explain why and what must change. With expertise on leading animal and human studies to end products, speakers will provide new insights into how clinical trials are conducted. Their common cause will be to argue that greater international cooperation and standards are required. That said, effective communication of clinical and societal benefits must be better coordinated to citizens, patients, health-care professionals, researchers, policy-makers, and society as a whole. Organizer: Aidan Gilligan (Irish), Founder, CEO of SciCom - Making Sense of Science; Contact: ag@xxxxxxxxxx<mailto:ag@xxxxxxxxxx> Moderator: Dr Klaus Bock (Danish), Champion Euroscience Open Forum 2014 Copenhagen, Member of the European Research Council’s Scientific Council Discussants: * Professor Anne Glover, (British), Chief Scientific Adviser to European Commission President, José Manuel Barroso * Wilson M. Compton, (USA), M.D., M.P.E., Director, Division of Epidemiology, Services and Prevention Research, National Institute on Drug Abuse, National Institutes of Health, U.S. Department of Health and Human Services Speakers: * Dr. Thomas Hartung (German), Professor and Chair for Evidence-based Toxicology, Director, Center for Alternatives to Animal Testing, Johns Hopkins University, Bloomberg School of Public Health, Dept. of Environmental Health Science Look back in anger? What clinical trials tell us about pre-clinical research<http://jhsph.us4.list-manage1.com/track/click?u=066d5d7abe2de2d5e04d214bf&id=c8cce2270f&e=4c7d58c42f> (PDF) * Jay Siegel (American), Chief Biotechnology Officer for Johnson & Johnson & Head of Pharmaceutical Global Regulatory Affairs for Janssen, Janssen Research & Development Product-orientated versus healthcare-orientated clinical trials * Dr. Paul J. Kenny (Irish), Associate Professor, Laboratory of Behavioral and Molecular Neuroscience, Department of Molecular Therapeutics, The Scripps Research Institute - Florida The latest clinical trial research on brain reward systems Registration and Details:http://www.aaas.org/meetings/2013/registration/<http://jhsph.us4.list-manage.com/track/click?u=066d5d7abe2de2d5e04d214bf&id=792df2402d&e=4c7d58c42f> ________________________________ Best wishes from all of us, The CAAT Team [http://gallery.mailchimp.com/066d5d7abe2de2d5e04d214bf/images/jhsph2c.jpg]<http://jhsph.us4.list-manage.com/track/click?u=066d5d7abe2de2d5e04d214bf&id=5657cd6830&e=4c7d58c42f> [http://gallery.mailchimp.com/066d5d7abe2de2d5e04d214bf/images/konstanzlogo.jpg] <http://jhsph.us4.list-manage.com/track/click?u=066d5d7abe2de2d5e04d214bf&id=df67940435&e=4c7d58c42f> [http://gallery.mailchimp.com/066d5d7abe2de2d5e04d214bf/images/tubes.jpg] CAAT Grants Program: Call for Preproposals Deadline: March 22, 2013 The Johns Hopkins Center for Alternatives to Animal Testing (CAAT) is soliciting projects that focus on the implementation of the NAS Report: Toxicity Testing in the 21st Century: A Vision and a Strategy in the following area: Proposals Relating to Toxicology: Maximum grant amount is $25,000 per year. Projects should be developed to provide understanding of mechanism/mode of action and to consider how one would be able to translate the mechanism to a method that can be used to evaluate/predict health consequences. To apply for a CAAT grant, complete the preproposal form here<http://jhsph.us4.list-manage.com/track/click?u=066d5d7abe2de2d5e04d214bf&id=ff8f47fdc3&e=4c7d58c42f> and return so that the submission reaches us no later than March 22, 2013. Full details on CAAT's grant program may be found here<http://jhsph.us4.list-manage.com/track/click?u=066d5d7abe2de2d5e04d214bf&id=2f1a54a613&e=4c7d58c42f>. follow on Twitter<http://jhsph.us4.list-manage.com/track/click?u=066d5d7abe2de2d5e04d214bf&id=735d957284&e=4c7d58c42f> | friend on Facebook<http://jhsph.us4.list-manage.com/track/click?u=066d5d7abe2de2d5e04d214bf&id=de80ce0362&e=4c7d58c42f> | forward to a friend<http://us4.forward-to-friend.com/forward?u=066d5d7abe2de2d5e04d214bf&id=71fccd3c68&e=4c7d58c42f> Copyright © 2013 Johns Hopkins Center for Alternatives to Animal Testing, All rights reserved. You are receiving this email as a friend or colleague of CAAT. US Office: 615 N. 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