LRI Innovative Science Award 2013 (http://www.cefic-lri.org/index.php?page=awards) Deadline for applications: 15 March 2013 The European Chemical Industry Council (Cefic), in conjunction with the Society of Environmental Toxicology and Chemistry (SETAC), the Association of European Toxicologists and European Societies of Toxicology (EUROTOX), the International Society of Exposure Sciences (ISES) and Chemical Week, is offering a €100,000 award to support promising new research in the field of exposure assessment to quantify human health risks using hazard data that could be generated at multiple scales of biological organization. The need to assess the human health risks of large numbers of chemicals, a desire to reduce our reliance on animal testing, and the recognition that risk assessment methodology should be improved are driving the development of mechanistic approaches that can be integrated into holistic schemes predictive of real-world human risks. Scientific advances to identify molecular initiating events, and higher order key events are useful to elucidate toxicity pathways and adverse outcomes, however alone they do not necessarily result in accurate predictions of human health risks. Considerably more research is needed if we are to have the scientific capabilities to quantify adverse outcome pathways, AOPs, for use in prospective and retrospective chemical risk assessments. Scientific challenges include: • the development of integrated approaches that consider relevant exposure metrics from source to dose, on multiple levels of integration (including time, space and biological scale) and scaled from molecular systems to individuals. • assessing exposure to chemicals in the context of multiple stressors. • the advancement of exposure based waiving approaches. • estimating internal exposure via the development of system based models (e.g. PBPK and biokinetic and biodynamic models) and the application of in vitro testing strategies to assessing adverse outcomes in humans. The ultimate goal will be to develop predictive systems models that integrate critical determinants of exposure and effects that relate to real-world human risks. The objective of this LRI Award is to stimulate innovative research, 'out-of-the-box' thinking and new approaches which will advance the understanding of the health relevance of exposure. The research should be complementary to the Long-range Research Initiative's (LRI) objectives, a chemical industry funded program that aims at enhancing scientific knowledge to help protect health and the environment. More information is available on the LRI website (http://www.cefic-lri.org[see "About LRI"]). The award is intended for a European-based scientist with less than ten years post-doctoral experience. Active involvement in interdisciplinary research, current academic track record, and access to appropriate networks will be considered in the selection. The LRI Innovative Science Award will be officially presented at the LRI Annual Workshop on 21 November 2013 in Brussels. The 2013 Awardee will be expected to present the results of his/her research supported by the Award at the LRI Annual Workshop in November 2014. Kristie Sullivan Secretary, ASCCT www.ascctox.org This email was sent to members of the American Society for Cellular and Computational Toxicology. Learn more at www.ascctox.org. To post, send to ascct@xxxxxxxxxxxxx. To unsubscribe, send an email with the subject line "unsubscribe" to ksullivan@xxxxxxxxxxx. To view an archive of list emails, visit www.freelists.org/archive/ascct.