[ascct] LRI Innovative Science Award applications being accepted

  • From: Kristie Sullivan <KSullivan@xxxxxxxx>
  • To: "ascct@xxxxxxxxxxxxx" <ascct@xxxxxxxxxxxxx>
  • Date: Wed, 6 Feb 2013 16:44:26 -0500

LRI Innovative Science Award 2013 
(http://www.cefic-lri.org/index.php?page=awards)
 
Deadline for applications: 15 March 2013
  
The European Chemical Industry Council (Cefic), in conjunction with the Society 
of Environmental Toxicology and Chemistry (SETAC), the Association of European 
Toxicologists and European Societies of Toxicology (EUROTOX), the International 
Society of Exposure Sciences (ISES) and Chemical Week, is offering a €100,000 
award to support promising new research in the field of exposure assessment to 
quantify human health risks using hazard data that could be generated at 
multiple scales of biological organization.
 
The need to assess the human health risks of large numbers of chemicals, a 
desire to reduce our reliance on animal testing, and the recognition that risk 
assessment methodology should be improved are driving the development of 
mechanistic approaches that can be integrated into holistic schemes predictive 
of real-world human risks. Scientific advances to identify molecular initiating 
events, and higher order key events are useful to elucidate toxicity pathways 
and adverse outcomes, however alone they do not necessarily result in accurate 
predictions of human health risks. Considerably more research is needed if we 
are to have the scientific capabilities to quantify adverse outcome pathways, 
AOPs, for use in prospective and retrospective chemical risk assessments. 
Scientific challenges include:
 
•  the development of integrated approaches that consider relevant exposure 
metrics from source to dose, on multiple levels of integration (including time, 
space and biological scale) and scaled from molecular systems to individuals. 
•  assessing exposure to chemicals in the context of multiple stressors. 
•  the advancement of exposure based waiving approaches. 
•  estimating internal exposure via the development of system based models 
(e.g. PBPK and biokinetic and biodynamic models) and the application of in 
vitro testing strategies to assessing adverse outcomes in humans. 
 
The ultimate goal will be to develop predictive systems models that integrate 
critical determinants of exposure and effects that relate to real-world human 
risks.
 
The objective of this LRI Award is to stimulate innovative research, 
'out-of-the-box' thinking and new approaches which will advance the 
understanding of the health relevance of exposure.
 
The research should be complementary to the Long-range Research Initiative's 
(LRI) objectives, a chemical industry funded program that aims at enhancing 
scientific knowledge to help protect health and the environment. More 
information is available on the LRI website (http://www.cefic-lri.org[see 
"About LRI"]).
 
The award is intended for a European-based scientist with less than ten years 
post-doctoral experience. Active involvement in interdisciplinary research, 
current academic track record, and access to appropriate networks will be 
considered in the selection.
 
The LRI Innovative Science Award will be officially presented at the LRI Annual 
Workshop on 21 November 2013 in Brussels. The 2013 Awardee will be expected to 
present the results of his/her research supported by the Award at the LRI 
Annual Workshop in November 2014.

Kristie Sullivan
Secretary, ASCCT
www.ascctox.org



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