[ascct] Fwd: CAATwalk: News and Updates
- From: Kristie Sullivan <KSullivan@xxxxxxxx>
- To: "ascct@xxxxxxxxxxxxx" <ascct@xxxxxxxxxxxxx>
- Date: Fri, 22 Mar 2013 16:58:19 -0400
Several interesting events and announcements from CAAT and CAAT EU.
Kristie Sullivan
Secretary, ASCCT
www.ascctox.org<http://www.ascctox.org>
Begin forwarded message:
From: Center for Alternatives to Animal Testing (CAAT)
<caat@xxxxxxxxx<mailto:caat@xxxxxxxxx>>
Subject: CAATwalk: News and Updates
Date: March 22, 2013 1:36:18 PM PDT
To: <kristilinamarie@xxxxxxxxx<mailto:kristilinamarie@xxxxxxxxx>>
Reply-To: Center for Alternatives to Animal Testing (CAAT)
<caat@xxxxxxxxx<mailto:caat@xxxxxxxxx>>
Updates from the Center for Alternatives to Animal Testing (CAAT)
Email not displaying correctly?
View it in your
browser<http://us4.campaign-archive1.com/?u=066d5d7abe2de2d5e04d214bf&id=54d2c6ac23&e=4c7d58c42f>.
[http://gallery.mailchimp.com/066d5d7abe2de2d5e04d214bf/images/caatlogo.2.jpg]<http://jhsph.us4.list-manage.com/track/click?u=066d5d7abe2de2d5e04d214bf&id=e701ba81c8&e=4c7d58c42f>
[http://gallery.mailchimp.com/27aac8a65e64c994c4416d6b8/images/twitter_24x24_p50.png]
<http://jhsph.us4.list-manage1.com/track/click?u=066d5d7abe2de2d5e04d214bf&id=4521bca644&e=4c7d58c42f>
[http://gallery.mailchimp.com/27aac8a65e64c994c4416d6b8/images/facebook_24x24_p50.png]
<http://jhsph.us4.list-manage1.com/track/click?u=066d5d7abe2de2d5e04d214bf&id=b0dc671965&e=4c7d58c42f>
CAATwalk March 22, 2013
Developing Microphysiological Systems for Use as Regulatory Tools—Challenges
and Opportunities
CAAT, along with The Food and Drug Administration (FDA), National Institutes of
Health, National Institute for Environmental Health Sciences (NIEHS), National
Center for Advancing Translational Science (NCATS), and the International
Consortium for Innovation and Quality in Pharmaceutical Development (IQ) are
collaborating to present this workshop. CAAT Director Thomas Hartung will chair
a session on "Inventing Microphysiological Systems: Cell Types, Tissues, and
How to Apply Them" and speak on good cell cultures and quality control. The
workshop’s goal is to provide a forum for academia, industry, and regulatory
agencies to address two objectives: 1) discuss essential elements needed to
develop microphysiological systems as regulatory tools, and 2) discuss pathways
to qualification as regulatory tools.
Information and
Registration<http://jhsph.us4.list-manage1.com/track/click?u=066d5d7abe2de2d5e04d214bf&id=d82e1449e0&e=4c7d58c42f>
CAAT Receives $2 Million Sub-grant as Part of Consortium Developing
“Body-on-a-Chip” Platform
CAAT is the recipient of a $2 million sub-grant to develop a body-on-a-chip
platform as part of a consortium led by Wake Forest University with funding
from the US Defense Threat Reduction Agency. The project aims to develop an
integrated organoid testing system (INGOTS), a modular, scalable, microfluidic
system with multi-tissue system integration (mimicking human organ function)
through the creation of resealable microfluidic devices capable of cell
culture and analysis. A key role for CAAT will be providing advice to the
consortium on quality assurance and validation, as well as supporting
metabalomics measurements and mitigation strategies for identifying alternative
cell systems. The work is closely related to the recent ALTEX article by Thomas
Hartung and Joanne Zurlo, Alternative approaches for medical countermeasures to
biological and chemical terrorism and
warfare.<http://jhsph.us4.list-manage2.com/track/click?u=066d5d7abe2de2d5e04d214bf&id=e6b8d1ea56&e=4c7d58c42f>
Martin L. Stephens Receives Society of Toxicology Enhancement of Animal Welfare
Award
Martin L. Stephens, PhD, was awarded the 2013 Society of Toxicology Enhancement
of Animal Welfare Award, becoming the third member of CAAT to receive the
honor. Alan Goldberg and Thomas Hartung were earlier recipients. Dr. Stephens
is a senior research associate at the CAAT, where he coordinates the Center’s
activities on evidence-based toxicology. Prior to joining Hopkins in October
2011, Dr. Stephens was vice president for animal research issues at The Humane
Society of the United States where he directed the Society’s efforts on behalf
of animals in laboratories. He served on the National Academy of Sciences
committee that wrote Toxicity Testing in the 21st Century: A Vision and a
Strategy, as well as on program committees for the World Congresses on the use
of animals and alternatives in the life sciences. He co-founded the Human
Toxicology Project Consortium, which seeks to accelerate the implementation of
pathway-based toxicity testing. Dr. Stephens has received the
Doerenkamp-Zbinden Award and the CAAT Recognition Award for his contributions
to animal protection and alternative methods.
Evidence-based Toxicology Collaboration (EBTC) Session at XIII International
Congress of Toxicology, Seoul, Korea (June 30-July 4, 2013)
The EBTC will be hosting a session at the Congress, with planned subjects to
include updates on the activities of the EBTC, methods and methodologies, and
the toolbox for assessment of tests and testing strategies. Congress
website<http://jhsph.us4.list-manage.com/track/click?u=066d5d7abe2de2d5e04d214bf&id=bc95aeff63&e=4c7d58c42f>.
2014 CAAT Science-based Refinement Awards: Call for Proposals
Attention veterinarians, lab technicians, animal technicians, and all who work
with laboratory animals: CAAT now is accepting proposals for the 2014
Science-based Refinement Awards (formerly the Animal Welfare Enhancement
Awards). The focus of these awards is to elicit scientific evidence to support
the enhancement of the housing, handling, and/or experimental situations for
laboratory animals. Deadline for submissions is September 30, 2013. See the
CAAT
website<http://jhsph.us4.list-manage1.com/track/click?u=066d5d7abe2de2d5e04d214bf&id=95abef0bc2&e=4c7d58c42f>
for more information.
Save the Date: Scientific Roadmap for the Future of Animal-free Systemic
Toxicity Testing: May 30-31, 2013
Organized by CAAT and hosted by FDA, with more than twelve co-sponsoring
organizations, this workshop will be held at the FDA Wiley Building in College
Park, Maryland. Discussions and presentations will address the roadmap outlined
in "A roadmap for the development of alternative (non-animal) methods for
systemic toxicity testing," by Basketter et al. in ALTEX
(PDF<http://jhsph.us4.list-manage2.com/track/click?u=066d5d7abe2de2d5e04d214bf&id=d85b327e8f&e=4c7d58c42f>).
This stakeholder forum will be modeled on the one held in Brussels in March,
2012, co-organized by numerous organizations and attended by some 150 experts.
For details contact Marilyn Principe:
mprincip@xxxxxxxxx<mailto:mprincip@xxxxxxxxx>
CAAT at the Society of Toxicology Annual Meeting
CAAT organized a satellite meeting at the 2013 Society of Toxicology Meeting in
San Antonio, Texas on March 14th: Updates on 21st Century Toxicology Activities
and Related Efforts: Invited Presentations and Open Microphone. Thomas Hartung
and Martin Stephens presented, as well as representatives from EPA, NIEHS, and
the Hamner Institutes for Biomedical Science. Also at the conference, Lena
Smirnova, CAAT Research Associate, presented a poster on our current work
elucidating effects of developmental toxicants on microRNA expression during
differentiation of LUHMES neuronal progenitor cells. The poster described the
different differentiation conditions: 2D vs 3D, as well as expression of neural
specific microRNA in course of LUHMES differentiation, and effects of two well
known developmental neurotoxicants, lead chloride and valproate, on miRNA
expression during neuronal differentiation of LUHMES cells. Helena Hogberg,
CAAT research associate, presented the FDA funded project “DNTox-21c:
Identification of pathways of developmental neurotoxicity for high throughput
testing by metabolomics” in platform session "Validation and Application of
Neurotoxicology In Vitro Methods."
Recent Editorial in Archives of Toxicology: Inflammatory Findings on Species
Extrapolations: Humans are Definitely No 70-kg Mice
A new editorial by Marcel Leist and Thomas Hartung as been published in
Archives of Toxicology. Excerpt: “The low predictivity of animal experiments in
research areas allowing direct comparisons of mouse versus human data puts
strong doubt on the usefulness of animal data as key technology to predict
human safety.” PDF
link<http://jhsph.us4.list-manage2.com/track/click?u=066d5d7abe2de2d5e04d214bf&id=3d513ddc05&e=4c7d58c42f>
to full paper.
Best wishes,
The CAAT Team
[http://gallery.mailchimp.com/066d5d7abe2de2d5e04d214bf/images/jhsph2c.jpg]<http://jhsph.us4.list-manage.com/track/click?u=066d5d7abe2de2d5e04d214bf&id=4523c75adf&e=4c7d58c42f>
[http://gallery.mailchimp.com/066d5d7abe2de2d5e04d214bf/images/konstanzlogo.jpg]
<http://jhsph.us4.list-manage.com/track/click?u=066d5d7abe2de2d5e04d214bf&id=2f76276402&e=4c7d58c42f>
[http://gallery.mailchimp.com/066d5d7abe2de2d5e04d214bf/images/tubes.jpg]
Upcoming Events
April 23-24, 2013
Workshop: Lessons Learned, Challenges, and Opportunities: The US Endocrine
Disruptor Screening
Program<http://jhsph.us4.list-manage1.com/track/click?u=066d5d7abe2de2d5e04d214bf&id=ed4686bd07&e=4c7d58c42f>
Research Triangle Park, NC
Co-sponored by CAAT
May 10, 2013
Developing Microphysiological Systems for Use as Regulatory Tools—Challenges
and
Opportunities<http://jhsph.us4.list-manage1.com/track/click?u=066d5d7abe2de2d5e04d214bf&id=7a700679a4&e=4c7d58c42f>
Silver Spring, MD
May 30-31, 2013
Joint US Workshop: Scientific Roadmap for the Future of Animal-Free Systemic
Toxicity Testing
College Park, MD
Details: mprincip@xxxxxxxxx<mailto:mprincip@xxxxxxxxx>
Full Listing of CAAT Programs
and
Activities<http://jhsph.us4.list-manage.com/track/click?u=066d5d7abe2de2d5e04d214bf&id=c09f061fee&e=4c7d58c42f>
Altweb Calendar of
Events<http://jhsph.us4.list-manage.com/track/click?u=066d5d7abe2de2d5e04d214bf&id=8e39036375&e=4c7d58c42f>
follow on
Twitter<http://jhsph.us4.list-manage.com/track/click?u=066d5d7abe2de2d5e04d214bf&id=76d076d53d&e=4c7d58c42f>
| friend on
Facebook<http://jhsph.us4.list-manage.com/track/click?u=066d5d7abe2de2d5e04d214bf&id=feda992c5f&e=4c7d58c42f>
| forward to a
friend<http://us4.forward-to-friend1.com/forward?u=066d5d7abe2de2d5e04d214bf&id=54d2c6ac23&e=4c7d58c42f>
Copyright © 2013 Johns Hopkins Center for Alternatives to Animal Testing, All
rights reserved.
You are receiving this email as a friend or colleague of CAAT.
US Office: 615 N. Wolfe St. W7032 • Baltimore, MD 21205
Phone: 410-614-4990 • Fax: 410-614-2871
European Office: University of Konstanz
POB 600 78457 Konstanz, Germany
Phone: +49-531-882233 • Fax: +49-7531-884156
unsubscribe from this
list<http://jhsph.us4.list-manage.com/unsubscribe?u=066d5d7abe2de2d5e04d214bf&id=611b893885&e=4c7d58c42f&c=54d2c6ac23>
| update subscription
preferences<http://jhsph.us4.list-manage.com/profile?u=066d5d7abe2de2d5e04d214bf&id=611b893885&e=4c7d58c42f>
Other related posts:
