[ SHOWGSD-L ] Re: was Cardiac and GSD's, now DM testing
- From: Pinehillgsds@xxxxxxx
- To: pbgs@xxxxxxxxxxxx, terryr@xxxxxxxxxxxx, pcooke212@xxxxxxxxxxx, showgsd-l@xxxxxxxxxxxxx
- Date: Tue, 1 Mar 2011 09:07:01 EST
I'm not going to go through this again, lol.
Personally, I'll wait until they do more research...I have work to do.
Kathy, member GSDCA, DVGSDC
Celebrating generations of Dual Titled TC'd Champions
visit _http://www.pinehillgsds.com/_ (http://www.pinehillgsds.com/)
In a message dated 3/1/2011 9:01:49 A.M. Eastern Standard Time,
pbgs@xxxxxxxxxxxx writes:
Ok I am getting confused...as I am reading this it says to me that the
mutated gene is seen in 70% of certin breeds and 40% in others. It looks
to
me to say that 70% of the dogs in say Boxers carry 1 or 2 sets of the
mutated gene. And in some others 40% of the dogs carry 1 or 2 sets of the
breed. I do not see ANYWHERE that it says the test is only 40% reliable??
It further says to test offspring and use it in a way to lower the
precentage of dogs in the gene pool carrying the mutation.
Here is what it says
A relatively high percentage of dogs in several breeds have the
predisposing
mutation. With the testing done thus far (thru February 2011), the
frequency
of the mutation is over 70% in Boxers, Pembroke Welsh Corgis, and Wire Fox
Terriers. There are another 10 breeds where the mutation frequency is over
40%. For breeds with a high frequency of the DM mutation, it will take
wise
use of the test and several generations to maintian a healthy and diverse
gene pool while reducing the prevalence of DM. It is important for
breeders
and owners to keep in mind all the traits present in an individual dog,
and
not to simply breed a test result. We encourage breeders to DNA test
potential breeding stock and consider the results of the DM test as part
of
their evaluation and decision-making process.
Rebecca Little
Peakes Brook German Shepherds
http://www.peakesbrookshepherds.net/
----- Original Message -----
From: <Pinehillgsds@xxxxxxx>
To: <pbgs@xxxxxxxxxxxx>; <terryr@xxxxxxxxxxxx>; <pcooke212@xxxxxxxxxxx>;
<showgsd-l@xxxxxxxxxxxxx>
Sent: Tuesday, March 01, 2011 8:51 AM
Subject: [ SHOWGSD-L ] Re: was Cardiac and GSD's, now DM testing
> scroll down...it was in my initial post:
>
> http://www.caninegeneticdiseases.net/DM/testDM.htm
>
> Kathy, member GSDCA, DVGSDC
> Celebrating generations of Dual Titled TC'd Champions
> visit _http://www.pinehillgsds.com/_ (http://www.pinehillgsds.com/)
>
>
> In a message dated 3/1/2011 8:19:41 A.M. Eastern Standard Time,
> pbgs@xxxxxxxxxxxx writes:
>
> Please enclose a link for where it says the precentages of reliabilty. I
> cannot seem to find that info thru OFA.
> Rebecca Little
> Peakes Brook German Shepherds
> http://www.peakesbrookshepherds.net/
> ----- Original Message -----
> From: <Pinehillgsds@xxxxxxx>
> To: <terryr@xxxxxxxxxxxx>; <pcooke212@xxxxxxxxxxx>;
> <showgsd-l@xxxxxxxxxxxxx>
> Sent: Tuesday, March 01, 2011 8:01 AM
> Subject: [ SHOWGSD-L ] was Cardiac and GSD's, now DM testing
>
>
>> Sure.
>>
>> I included the link for the company who developed (and is continuing
to
>> develop I guess) the test used by the OFA. They are looking for a
>> mutation
>> of a marker when they test and their results depend on if they find the
>> marker on one DNA strand, both, or neither.
>>
>> I quoted from the top of their web site ""A relatively high percentage
>> of
>> dogs in several breeds have the
>>> predisposing mutation. With the testing done thus far (thru February
>>> 2011), the
>>> frequency of the mutation is over 70% in Boxers, Pembroke Welsh
>>> Corgis,
>>> and
>>> Wire Fox Terriers. There are another 10 breeds where the mutation
>>> frequency is
>>> over 40%."
>>
>> So, as of February 2011 GSDs aren't in the 70%. The company isn't
>> specific so I'm not even certain that we are in the 40%.
>>
>> There had been testing and research that was being done in FL, which
was
>> specific to our breed. (Not sure of the status of that but I know the
>> GSDCA
>> gave then $$$$). There has been some concern that markers for different
>> breeds were at different locations on the DNA strand. There has even
> been
>> speculation that the disease is actually different from breed to breed;
>> one
>> similar to MS, one closer to Lou Gherig's (sp????).
>>
>> WHEN WE DO THIS TEST ARE WE REALLY SCREENING OUR DOGS FOR THE TYPE OF
>> MARKER THAT WOULD INDICATE DM IN SAY...A CORGI?????
>>
>> Ginny has really done her home work on this and I know can explain it
> much
>> better than I.
>>
>> So, back to the test recognized by the OFA. I guess my concern is,
>> (let's
>> give the test the benefit of the doubt and assume for sake of argument
>> that the test is 40% reliable) and let's say a dog is tested clear.
By
>> the
>> company's own admission, the most we can expect is that the test is
40%
>> reliable. THE MOST!
>>
>> Now, I applaud continuing research and I'm ALL ABOUT breeding healthy
>> dogs. Personally, I am relying on pouring over pedigrees for now. A
>> test that
>> may or may not be 40% reliable for our breed....hmmmm....
>>
>> I agree this is a horrific disease (thankfully, knocking on wood, I've
>> never had it). For now though, give me the pedigree rather than a
> test
>> that
>> at best, by the company's own admission, as recent as lat month, is at
>> best
>> 40%.
>>
>>
>>
>>
>> Kathy, member GSDCA, DVGSDC
>> Celebrating generations of Dual Titled TC'd Champions
>>
>> visit _http://www.pinehillgsds.com/_ (http://www.pinehillgsds.com/)
>>
>>
>> In a message dated 2/28/2011 8:10:56 P.M. Eastern Standard Time,
>> terryr@xxxxxxxxxxxx writes:
>>
>> Kathy,
>> I am sorry but I do not understand how the quote you included about
DM
>> supports your opinion. Could you expound on it.
>> ----- Original Message -----
>> From: <Pinehillgsds@xxxxxxx>
>> To: <pcooke212@xxxxxxxxxxx>; <showgsd-l@xxxxxxxxxxxxx>
>> Sent: Monday, February 28, 2011 6:30 PM
>> Subject: [ SHOWGSD-L ] Re: Cardiac and GSD's
>>
>>
>>> Paula, it's the first site that comes up on google:
>>>
>>> _http://www.caninegeneticdiseases.net/DM/testDM.htm_
>>> (http://www.caninegeneticdiseases.net/DM/testDM.htm)
>>>
>>> I'm quoting:
>>>
>>> "A relatively high percentage of dogs in several breeds have the
>>> predisposing mutation. With the testing done thus far (thru February
>>> 2011), the
>>> frequency of the mutation is over 70% in Boxers, Pembroke Welsh
> Corgis,
>>> and
>>> Wire Fox Terriers. There are another 10 breeds where the mutation
>>> frequency is
>>> over 40%."
>>>
>>> This is the test used by the OFA. So are we in the 40%????? (You
>>> feel
>>> "OK" w/ that????) I'm not even sure if we are in the 40%...again,
>>> Ginny
>>> Altman posted a while back, she was far more eloquent than I, but
it
>>> appears
>>> that the marker is NOT located in the same place for all
> breeds...does
>>> anyone
>>> know if the research specific to our breed has been continued in
>>> FL????
>>>
>>>
>>> Kathy, member GSDCA, DVGSDC
>>> Celebrating generations of Dual Titled TC'd Champions
>>> visit _http://www.pinehillgsds.com/_ (http://www.pinehillgsds.com/)
>>>
>>>
>>
>>
>>
>>
>>
>
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> POST is Copyrighted 2011. All material remains the property of the
> original author and of GSD Communication, Inc. NO REPRODUCTIONS or
> FORWARDS of any kind are permitted without prior permission of the
> original author AND of the Showgsd-l Management. ALL RIGHTS RESERVED.
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> Each Author is responsible for the content of his/her post. This group
> and its administrators are not responsible for the comments or opinions
> expressed in any post.
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> ALL PERSONS ARE ON NOTICE THAT THE FORWARDING, REPRODUCTION OR USE IN
ANY
> MANNER OF ANY MATERIAL WHICH APPEARS ON SHOWGSD-L WITHOUT THE EXPRESS
> PERMISSION OF ALL PARTIES TO THE POST AND THE LIST MANAGEMENT IS
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> BE PROSECUTED.
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POST is Copyrighted 2011. All material remains the property of the original
author and of GSD Communication, Inc. NO REPRODUCTIONS or FORWARDS of any kind
are permitted without prior permission of the original author AND of the
Showgsd-l Management. ALL RIGHTS RESERVED.
Each Author is responsible for the content of his/her post. This group and its
administrators are not responsible for the comments or opinions expressed in
any post.
ALL PERSONS ARE ON NOTICE THAT THE FORWARDING, REPRODUCTION OR USE IN ANY
MANNER OF ANY MATERIAL WHICH APPEARS ON SHOWGSD-L WITHOUT THE EXPRESS
PERMISSION OF ALL PARTIES TO THE POST AND THE LIST MANAGEMENT IS EXPRESSLY
FORBIDDEN, AND IS A VIOLATION OF LAW. VIOLATORS OF THIS PROHIBITION WILL BE
PROSECUTED.
For assistance, please contact the List Management at admin@xxxxxxxxxxx
VISIT OUR WEBSITE - http://showgsd.org
SUBSCRIPTION:http://showgsd.org/mail.html
NATIONAL BLOG - http://gsdnational.blogspot.com/
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