Well Doris, there are a couple of things that come to mind right off the bat...Mycoplasma , Herpes, and simply a bacterial infection of some nature. With Mycoplasma, often there will be evidence of the pups starting to die around 53 days..so some will be more developed as they die over a period of 10 days....With Mycoplasma, there are often very small pups born alive and then die in a day or so..When I have a litter with any tiny pups I will give the normal pups son baytrill injections immediatly..like 1/20th of a cc for a 12 oz pup... With Herpes, the pups may look normal at birth and then die over a period of a few days. They usually have tonic seizures...They stiffen out like a skydiver as he leaves the plane. They will remain in that seizure for almost a minute then relax and again go into another seizure in a short time. They then may be OK for a matter of hours and the process repeats.....On the other hand they may just fade...Impression smears from the liver is the best way to find the virus bodies.Supposedly, the bitch will only have one litter that will die. She is supposed to develop antibodies against Herpes so that her next litter will get colostrum with antibodies and thus avoid the Herpes developing...NOT so all the time...I had a Rott who had a first litter die...we checked her and she had Herpes...Next litter we thought the pups would be safe..not so ..they all died..The third litter we too some on the dams blood at 55 days of her pregnancy, separated the serum, then froze it until the pups were born. At birth I gave each pup 1cc of serum by mouth and all lived..finally. Other bacterial infections can be cultured from the dead puppies livers, lungs, peritoneal cavities...Also the fetal membranes....I do think if you are losing pups it is wise to give the living puppies Baytrill injections...And I done think you are saving misfits that were meant to die! Chuck kruger dvm ============================================================================ POST is Copyrighted 2004. All material remains the property of the original author and of GSD Communication, Inc. NO REPRODUCTIONS or FORWARDS of any kind are permitted without prior permission of the original author AND of the Showgsd-l Management. ALL RIGHTS RESERVED. ALL PERSONS ARE ON NOTICE THAT THE FORWARDING, REPRODUCTION OR USE IN ANY MANNER OF ANY MATERIAL WHICH APPEARS ON SHOWGSD-L WITHOUT THE EXPRESS PERMISSION OF ALL PARTIES TO THE POST AND THE LIST MANAGEMENT IS EXPRESSLY FORBIDDEN, AND IS A VIOLATION OF LAW. VIOLATORS OF THIS PROHIBITION WILL BE PROSECUTED. For assistance, please contact the List Management at admin@xxxxxxxxxxxx VISIT OUR WEBSITE - http://www.showgsd.org ============================================================================