[optimal] Re: ICG dye
- From: CPMC Ophthalmic Diagnostic Center <cpmceyelab@xxxxxxxxxxxxxxxx>
- To: <optimal@xxxxxxxxxxxxx>
- Date: Tue, 22 Nov 2011 12:42:05 -0800
Stuart
We ALWAYS appreciate what you bring to the party!
Denice Barsness, CRA, COMT, ROUB, CDOS, FOPS
Ophthalmic Diagnostic Center
CPMC Department of Ophthalmology
2100 Webster Street Suite 212
San Francisco CA 94115
(415) 600-3937 FAX (415) 600-6563
From: optimal-bounce@xxxxxxxxxxxxx [mailto:optimal-bounce@xxxxxxxxxxxxx]
On Behalf Of stu weedn
Sent: Tuesday, November 22, 2011 12:26 PM
To: optimal@xxxxxxxxxxxxx
Subject: [optimal] Re: ICG dye
Friends,
The clearance rates of Fluorescein and ICG and the relatioship these may
have to early, mid and late phase time frames has been of some interest
to me for quite awhile. I will say upfront that I believe the equipment
current and in past years may have more bearing on this discussion than
the products. I do not pretend to be a scientist and most of you have
much greater knoweldege of this dicussion than I, however as a vendor of
both fluorescein and ICG and will weigh in with a couple of
industry/peer reviewed statistics.
First ICG
European Journal of Clinical Pharmacology May 2008 " Indocyanine Green
has a half life of 2-4 minutes" sorry some paraphrasing
Pulsion medical Systems ICG package insert:
In angiography of the eye less than 4% of the initial concentration of
ICG is present in circulation.
In healthy subjects ICG dissaperance is 18-24% per minute with a normal
biological half life of 2.5- 3.0 min.
Fluorescein:P
Clinical trials.gov identifier NCT01042171
This study states sodium fluorescein has a 10 min. half life
Pub Med peer reviewed article as of Oct. 20 2009
Fluorescein in Plasma has a half life of 23.5 min
Novartis package insert for Sodium Fluorescein for inj full prescribing
information
terminal half lives of fluorescein in plasma is 23.5 min
Sorry for all the stats but one of my questions has always been what is
being seen in circulation vs staining.
Financial Interest
Stuart Weedn
Opollo Ophthalmics inc.
Stuart Weedn
Apollo Ophthalmics inc.
(c) 949-689-0293
(w)800-603-4164
apolloophthalmics.com <http://www.apolloophthalmics.com/>
stuweedn@xxxxxxxxx
________________________________
From: Eric Kegley <ekegley@xxxxxxxxxxxxxxxxx>
To: optimal@xxxxxxxxxxxxx
Sent: Tuesday, November 22, 2011 10:20 AM
Subject: [optimal] Re: ICG dye
Denice,
I feel your joy.
EK
Eric Kegley, CRA, COA
Senior Clinical Trials Photographer
Retina Consultants of Houston
6560 Fannin St., Suite 750
Houston, TX 77030
Main 713 524-3434
Fax 713 524-3220
-----Original Message-----
From: optimal-bounce@xxxxxxxxxxxxx [mailto:optimal-bounce@xxxxxxxxxxxxx]
On
Behalf Of CPMC Ophthalmic Diagnostic Center
Sent: Tuesday, November 22, 2011 11:58 AM
To: optimal@xxxxxxxxxxxxx
Subject: [optimal] Re: ICG dye
I am still in awe of the simultaneous FA/ICG features of the Spectralis.
No
financial interest. Just thrilled to perform FA/ICG so effortlessly,
with
so little dye. Sensor is so sensitive we can get three patients from
one
vial of ICG without degradation of quality. Focusing back and forth
between
choroidal/retinal planes effortless. My two cents.
D.
Denice Barsness, CRA, COMT, ROUB, CDOS, FOPS Ophthalmic Diagnostic
Center
CPMC Department of Ophthalmology 2100 Webster Street Suite 212 San
Francisco
CA 94115
(415) 600-3937 FAX (415) 600-6563
-----Original Message-----
From: optimal-bounce@xxxxxxxxxxxxx [mailto:optimal-bounce@xxxxxxxxxxxxx]
On
Behalf Of Krista Wendland
Sent: Tuesday, November 22, 2011 7:39 AM
To: optimal@xxxxxxxxxxxxx
Subject: [optimal] Re: ICG dye
Hi Steve,
Thanks for your reply. We currently have the Zeiss FF450 which does not
have ICG capabilities however we are in the market to buy a new camera
with
AF and ICG. In January we will be trying the Heidelberg HRA and TopCon
TRC
50DX to see which camera we prefer. It is within this trial period that
the
doctors want to do a few ICG images. I didn't realize you could mix the
FA
and ICG dyes. I'm sure our doctors will find that useful as well.
Thanks for your help
Krista
Sent from my iPhone
On Nov 22, 2011, at 6:14 AM, "Steve Lusk" <slusk@xxxxxxxxxxxxx> wrote:
> Yes it is a reconstitute. You should only mix it when you're ready to
use.
We mix it in a 10cc syringe using 7cc of solvent w/ ICG and 3cc of
flourescein sodium. Our procedure is to inject the "cocktail" and shoot
FA
through A/V mid phase then switch to ICG. the ICG will stain at a slower
rate and will remain in the blood stream a bit longer than FA. effective
lates are for us between 15 and 30 minutes or whenever we determine
pathology. You should do both FA and ICG together (or at least have a
recent
FA) as to facilitate the overlay process. I hesitate to ask but is your
system ICG ready? It does require additional filters that aren't
normally
included in modern systems. ICG has kind of gone away for some with the
availability of SD-OCT. Ask any questions, we can help. I'm sure
someone
will have a procedure that best fits your setup and equipment.
> Hope this helps,
> Steve
>
>
> Steve Lusk, CRA
> Vistar Eye Center Retina Consultants
> 5296 Peters Creek Road
> Roanoke, VA 24019
> Phone: (540) 342-3400 ext. 4731
> Fax: (540) 362-1155
> slusk@xxxxxxxxxxxxx
> www.vistareye.com <http://www.vistareye.com/>
>
>
>
> ________________________________
>
> From: optimal-bounce@xxxxxxxxxxxxx on behalf of Krista Wendland
> Sent: Mon 11/21/2011 7:57 PM
> To: optimal@xxxxxxxxxxxxx
> Subject: [optimal] ICG dye
>
>
>
> We have never used ICG dye in our FA clinic and our docs would like to
try
it on a few patients. It's my understanding that the dye is sold in
vials
and then has to be mixed with a solution and used within a certain time
frame. Is this correct? I could use any advice and/or suggestions from
anyone who is familiar with ICG. I'm also looking for a cheap place to
purchase a small amount. Our clinic is in BC, Canada so we have to be
wary
of border issues.
> Thanks for your help!
>
> Krista Peters, COA
> Retina Surgical Associates
>
>
> Sent from my iPhone
>
>
> <winmail.dat>
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