[net-gold] SPORTS: MEDICINE : MEDICAL: DISEASES: DIABETES : PHYSICAL EXERCISE AND FITNESS: BENEFITS : WOMEN : CHILDREN : PARENTS AND PARENTING : MEDICAL: HEREDITY: Can Exercise Keep Moms From Passing on Diabetes?
- From: "David P. Dillard" <jwne@xxxxxxxxxx>
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- Date: Sat, 1 Feb 2014 12:32:48 -0500 (EST)
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SPORTS: MEDICINE :
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PHYSICAL EXERCISE AND FITNESS: BENEFITS :
WOMEN :
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Can Exercise Keep Moms From Passing on Diabetes?
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Can Exercise Keep Moms From Passing on Diabetes?
Posted by Josh Barney-Virginia
January 29, 2014
Futurity
Health and Medicine
Source: University of Virginia
http://www.futurity.org/can-exercise-keep-moms-passing-diabetes/
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Exercise during pregnancy can help protect the unborn offspring of obese
mothers from diabetes and other health problems in later life, research
with mice suggests.
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Researchers have determined that exercise during pregnancy prevented a
damaging epigenetic effect of the mothers obesityan effect believed to put
chemical marks on genes and lead to diabetes in the offspring. The
researchers identified the specific gene involved, providing an important
target for developing drugs that would prevent the undesired effect.
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While the researchers were focused primarily on diabetes, the findings
could have important implications for many other conditions.
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Disease transmission from parent to offspring is not limited to diabetes
but appears to be the case with many, many diseases, says Zhen Yan of
University of Virginias Robert M. Berne Cardiovascular Research Center.
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There is accumulating evidence suggesting diseases ranging from
atherosclerosis to diabetes to schizophreniaall these diseases we talk
about these daysare influenced by maternal condition.
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The study was based on the idea of developmental programmingthat the
condition and behavior of the mothers affect the health of their offspring
not just when theyre born, but throughout their life.
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The complete article may be read at the URL above.
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Exercise prevents maternal high-fat diet-induced hypermethylation of the
Pgc-1? gene and age-dependent metabolic dysfunction in the offspring
Rhianna C. Laker1,4,
Travis S. Lillard1,
Mitsuharu Okutsu1,4,5,
Mei Zhang1,4,5,
Kyle L. Hoehn2,4,
Jessica J. Connelly1,3,* and
Zhen Yan1,2,3,4,5,*
+ Author Affiliations
1Departments of Medicine
2Pharmacology
3Molecular Physiology & Biological Physics
4Center for Skeletal Muscle Research at Robert M. Berne Cardiovascular
Research Center
5University of Virginia School of Medicine, Charlottesville, VA;
Cardiovascular & Metabolic Disorders Program, Duke-NUS Graduate Medical
School, Singapore
*Co-corresponding authors: Jessica J. Connelly, Email:
jessica.connelly@xxxxxxxxxxxx; and Zhen Yan, Email: zhen.yan@xxxxxxxxxxxx
Published online before print
January 15, 2014,
doi: 10.2337/db13-1614
Diabetes
January 15, 2014
http://diabetes.diabetesjournals.org/
content/early/2014/01/03/db13-1614.abstract
OR
http://tinyurl.com/p55hnfz
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Temple University
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