[lit-ideas] Genentech tries to block effective medicine in order to profit
- From: "Andreas Ramos" <andreas@xxxxxxxxxxx>
- To: "Lit-Ideas" <lit-ideas@xxxxxxxxxxxxx>
- Date: Sun, 18 Jun 2006 19:42:26 -0700
An example of corporate greed.
Drugs firm blocks cheap blindness cure
Company will only seek licence for medicine that costs 100 times more
Sarah Boseley, health editor
Saturday June 17, 2006
A major drug company is blocking access to a medicine that is cheaply and effectively saving
thousands of people from going blind because it wants to launch a more expensive product on
Ophthalmologists around the world, on their own initiative, are injecting tiny quantities of
a colon cancer drug called Avastin into the eyes of patients with wet macular degeneration,
a common condition of older age that can lead to severely impaired eyesight and blindness.
They report remarkable success at very low cost because one phial can be split and used for
dozens of patients.
But Genentech, the company that invented Avastin, does not want it used in this way. Instead
it is applying to license a fragment of Avastin, called Lucentis, which is packaged in the
tiny quantities suitable for eyes at a higher cost. Speculation in the US suggests it could
cost £1,000 per dose instead of less than £10. The company says Lucentis is specifically
designed for eyes, with modifications over Avastin, and has been through 10 years of testing
to prove it is safe.
Unless Avastin is approved in the UK by the National Institute for Clinical Excellence
(Nice) it will not be universally available within the NHS. But because Genentech declines
to apply for a licence for this use of Avastin, Nice cannot consider it. In spite of the
growing drugs bill of the NHS, it will appraise, and probably approve, Lucentis next year.
Although Nice's role is to look at cost-effectiveness, it says it cannot appraise a drug and
pass it for use in the NHS unless the drug is referred to it by the Department of Health.
The department says its hands are tied.
"The drug company hasn't applied for it to be licensed for this use. It wouldn't be referred
to Nice until they have made the first move," said a Department of Health spokeswoman. "They
need to step up and get a licence. If they are not getting it licensed, why aren't they?"
New drugs for the condition are badly needed: those we have now only slow the progression to
blindness. With Avastin, many patients get their sight back with just one or two injections.
Avastin was first used on human eyes by Philip Rosenfeld, an ophthalmologist in the US, who
was aware of animal studies carried out by Genentech that showed potential in eye
conditions. This unlicensed use of Avastin has spread across continents entirely by word of
mouth from one doctor to another. It has now been injected into 7,000 eyes, with
Professor Rosenfeld has published his results and a website has been launched in the US to
collate the experiences of doctors from around the world. But although the evidence is good,
regulators require randomised controlled trials before they grant licences, which generally
only the drug companies can afford to carry out.
Prof Rosenfeld said the real issue was drug company profits. "This truly is a wonder drug,"
he said. "This shows both how good they [the drug companies] are and on the flip side, how
greedy they are." He would like to see governments fund clinical trials of drugs such as
Avastin in the public interest.
Rising drug bills are a big problem on both sides of the Atlantic. In the UK, said David
Wong, chairman of the scientific committee of the Royal College of Ophthalmologists, doctors
are fighting battles to persuade primary care trusts to pay for drugs to stop their patients
going blind while they wait for Nice to decide on Lucentis and another expensive drug called
Macugen. That decision is not expected before the end of next year.
About 20,000 people are diagnosed with age-related macular degeneration in the UK each year.
"From the patient's point of view, if they have an eye condition that deteriorates very
quickly, there is no question of waiting," said Professor Wong. "We're talking about days
and weeks, rather than months. The question is should we do nothing and say there is no
randomised controlled trial to prove Avastin is of value?" He called for primary care trusts
to agree to pay for the planned phasing-in of new drugs for the condition.
Last night Genentech said its main concern over the use of Avastin to treat eye conditions
was patient safety. "While there are some small, single-centre, uncontrolled studies of
Avastin being performed, safety data on patients who are treated with Avastin off-label is
not being collected in a standard or organised fashion," said a spokeswoman for the company.
Pharmaceutical firms say they need to launch drugs at high prices because of the hundreds of
millions of pounds spent on developing them. Critics point out that the company's
calculations also include the marketing budget.
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