Bsed upon the event ids..Its seems that you are experiencing a Virtual memory fragmentation issue. Where in at a particular point of time the memory blocks availabe for Exchange is very less and it stops responding this happens gradually and the mail flow stops. Doing a reboot of the server solves the problem. You should understand that this is nothing to do with the Physical memory. This issue is caused as exchange server is not configured properly. To resolve this issue, please visit the Web site given below. http://support.microsoft.com/default.aspx?kbid=325044 (325044 HOW TO: Troubleshoot Virtual Memory Fragmentation in Exchange 2003 and Exchange 2000) http://support.microsoft.com/default.aspx?scid=kb;en-us;329864 (329864 Troubleshooting Virtual Memory Fragmentation on Microsoft Exchange 2000 Servers) http://support.microsoft.com/default.aspx?scid=kb;en-us;296073 (296073 Monitoring for Exchange 2000 Memory Fragmentation) http://support.microsoft.com/default.aspx?scid=kb;en-us;314736 (314736 /3GB Switch Can Cause Memory Fragmentation on Exchange Server) http://support.microsoft.com/default.aspx?scid=kb;en-us;317411 (317411 Gather Data to Troubleshoot Exchange Virtual Memory Issues) http://support.microsoft.com/default.aspx?scid=kb;en-us;324118 (324118 The ESE Database Engine Contributes to VM Fragmentation) Manoj Enterprise Messaging Support