TO DEMONSTRATE AND ANSWER QUESTIONS ABOUT EPA’S iCSS DASHBOARDS AND ILSI/HESI’S
RISK21 WEB TOOL
November 18, 2015
1:30-5:30 PM – EPA Potomac Yards
Crystal City, VA
Co-sponsored by EPA/ORD and FDA/CFSAN in conjunction with SOT’s Future Tox III
Meeting on November 19-20, 2015.
No registration fee but registration is required as there is limited seating
Please contact Suzy Fitzpatrick at
further information or to register.
1:30-4:00Come learn about EPA’s new version of the interactive Chemical Safety
for Sustainability ToxCast Dashboard and the Adverse Outcome Pathway Wiki.
The iCSS ToxCast Dashboard is an interactive tool for distribution,
visualization, and use of chemical screening data from the Toxicity Forecaster
(ToxCast) project and the Toxicity Testing in the 21st century (Tox21)
collaboration. The iCSS ToxCast Dashboard integrates data from various sources
including: ToxCast and Tox21 high-throughput data from screening 8,000
chemicals; chemical exposure data and prediction models from ExpoCast; high
quality chemical structures and annotations from DSSTox; physical chemical
properties; and chemicals listed by associated categories of chemical and
product use from the CPCat database. The complete ToxCast Phase II data
(including assay summary activity files, assay description files, effect and
endpoint data files from animal toxicity studies, concentration response data
files & chemical library and structure files) are available on the ToxCast Data
EPA, in collaboration with the international scientific community, the European
Joint Research Center and the Organization of Economic Cooperation and
Development are developing AOP tools to facilitate the use of AOPs to evaluate
chemical risks to human health and the environment. The AOP wiki is the first
publicly released module of the larger AOP Knowledgebase (AOP KB). The AOP Wiki
is an interactive and virtual encyclopedia for AOP development. It is intended
to help the international scientific community recognize and agree on AOPs. An
AOP is a conceptual framework that shows existing knowledge concerning the
linkage between a chemical interacting with a biological process, a direct
molecular initiating event, and an adverse human or environmental health
4:00-5:30- ILSI/HESI RISK 21 Web tool – get hands-on experience in the use of
the RISK21 web tool using illustrative case studies. The RISK21 approach and
web tool are introduced in the following publications. More information is
available at www.risk21.org<http://www.risk21.org>.
* Pastoor TP, Bachman AN, Bell DR, Cohen SM, Dellarco M, Dewhurst IC, Doe
JE, Doerrer NG, Embry MR, Hines RN, et al: A 21st century roadmap for human
health risk assessment. Critical Reviews in Toxicology 2014, 44:1-5.
* Embry MR, Bachman AN, Bell DR, Boobis AR, Cohen SM, Dellarco M, Dewhurst
IC, Doerrer NG, Hines RN, Moretto A, et al: Risk assessment in the 21st
century: Roadmap and matrix. Critical Reviews in Toxicology 2014, 44:6-16.