does this happen with any other card? Check your startup folder in start menu / programs, tell me if bookport launcher is listed there. That's a little program which runs in the background and waits for the book port to be connected, then automatically opens book port transfer when it detects the device. If bookport launcher is not running, this won't work, and furthermore, bookport transfer won't even detect the book port once you launch it. If you need to, write back to the list and i'll give you instructions on how to get that back up and running.