[ascct] Launch of 2 OECD Test Guidelines on human hazard endpoint skin sensitisation
- From: Kristie Sullivan <KSullivan@xxxxxxxx>
- To: "ascct@xxxxxxxxxxxxx" <ascct@xxxxxxxxxxxxx>
- Date: Fri, 6 Feb 2015 09:05:34 -0500
6/2/2014 - The OECD has just published two new Test Guidelines on human health
hazard endpoint skin sensitisation. Skin sensitisation refers to an allergic
response following skin contact with the tested chemical, as defined by the
United Nations Globally Harmonized System of Classification and Labelling of
Chemicals (UN GHS). Test Guideline 442C concerns an In Chemico procedure for
the Direct Peptide Reactivity Assay and addresses the molecular initiating
event leading to the skin sensitisation. Test Guideline 442D looks at an in
vitro procedure, namely the ARE-Nrf2 luciferase test method, and looks to
address the second key event on the adverse outcome pathway leading to skin
sensitisation. Both of these Test Guidelines set out the procedures for
supporting the discrimination between skin sensitisers and non-sensitisers in
accordance with the UN GHS. They are the first two in a series of in vitro
methods that will gradually replace in vivo animal Test Guidelines on skin
sensitisation; more of these alternative methods are detailed in the work plan
of the Test Guidelines
Programme<http://www.oecd.org/chemicalsafety/testing/Declassified-TGP-Workplan-28-July-2014.pdf>.
· Test No. 442C: In Chemico Skin Sensitisation (Direct Peptide
Reactivity Assay
(DPRA)<http://www.oecd-ilibrary.org/environment/test-no-442c-in-chemico-skin-sensitisation_9789264229709-en>
· Test No. 442D: In Vitro Skin Sensitisation (ARE-Nrf2 Luciferase Test
Method)<http://www.oecd-ilibrary.org/environment/test-no-442d-in-vitro-skin-sensitisation_9789264229822-en>
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- » [ascct] Launch of 2 OECD Test Guidelines on human hazard endpoint skin sensitisation - Kristie Sullivan
