[smartdoctor] [Fwd: 5 Minutes of International Medicine]

  • From: htiljak@xxxxxx
  • To: smartdoctor@xxxxxxxxxxxxx
  • Date: Wed, 20 Apr 2011 00:30:15 +0200 (CEST)

--------------------------- Originalna poruka ----------------------------
Naslov: 5 Minutes of International Medicine
Šalje:  "BMJ Group" <email@xxxxxxxxxxxxxxxxxxx>
Datum:  Uto, travanj 19, 2011 10:33 am
Prima:  htiljak@xxxxxx
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5 Minutes of International Medicine from BMJ Group - April 2011

Dear Colleague,

5 Minutes of International Medicine from BMJ Group is our monthly email
alerting service providing you with free access to the latest and most
relevant articles from our wide range of products.


Big headed babies

Many family doctors still check child development, and may see lots of
babies with a head circumference above the 99th centile. Do these babies
need to be referred? This study compared head circumference according to
the new UK-WHO standard with the UK 1990 reference. The UK-WHO standard
identified many more infants with heads above the 98th centile, and
infants with rapid head growth (defined as crossing upwards through two
major centile bands) than the UK 1990 reference. Referral in these cases
wouldn't be necessary.

http://emails.bmjgroup.com/HS?a=ENX7CqkHKmjD8SA9MKJOsgznGHxKLLyQpvcStGb5lw8W0bBhOG5mpqVsje_Hhe-mDFEr
Source: Archives of Disease in Childhood 2011;96:386-388

Should non insulin dependent diabetics self monitor their glucose?
Anyone who uses insulin should be encouraged to use self monitoring of
blood glucose (SMBG). But is it useful in diabetic patients who don't need
insulin? The short answer from a systematic review is "not proven." A
commentary on the review says that there is no clinically relevant benefit
and that SMBG can worsen a patient's quality of life. However, there may
be subgroups of patients who would benefit from SMBG; a meta-analysis is
under way.

http://emails.bmjgroup.com/HS?a=ENX7CqkHKmjD8SA9MKJOsgznGHxKLLyQp_cStGb5lw8W0bBhOG5mpqVsje_Hhe-mDFEo
Source: Evidence Based Medicine 2011; 16:42-43

What to add to metformin?

Metformin is the first line drug for type 2 diabetes. Most patients will
need additional therapy in time. Which is best? This meta-analysis shows
they are similarly effective at lowering blood glucose when added to
metformin. The newer therapies cause less hypoglycaemia and keep weight
stable or reduce it. However, their long term effects are less well known.
The options are:

*  Sulphonylureas/glinides - have a risk of hypoglycaemia, but their long
term effects are well documented
*  Thiazolidinediones (AGI, DPP4 inhibitors and GLP-1 analogues)  - newer
drugs with less well known long term effects but have a lower risk of
hypoglycaemia compared to sulphonylureas and the glinides.
*  DPP4 inhibitors and the AGI - have a neutral effect on weight
*  GLP-1 analogues - associated with highly significant weight loss

http://emails.bmjgroup.com/HS?a=ENX7CqkHKmjD8SA9MKJOsgznGHxKLLyQpPcStGb5lw8W0bBhOG5mpqVsje_Hhe-mDFEp
Source: Evidence Based Medicine 2011; 16:39-40


Abdominal angina

Chronic gastrointestinal ischaemia (CGI) or abdominal angina, is more
common than previously thought. Classic symptoms are
â&#65533;˘        postprandial pain
â&#65533;˘        weight loss due to fear of pain after eating
â&#65533;˘        abdominal bruit on examination.
These studies showed symptoms may be more varied than this triad.  CT
angiography and assessment of mucosal perfusion can help to make the
diagnosis. Endovascular or surgical revascularisation can be highly
successful.

Source: Gut 2011;60:722-737 doi:10.1136
http://emails.bmjgroup.com/HS?a=ENX7CqkHKmjD8SA9MKJOsgznGHxKLLyQQvcStGb5lw8W0bBhOG5mpqVsje_Hhe-mDFFH



Compiled by Dr Ann Robinson

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5 Minutes of International Medicine from BMJ Group - April 2011

Dear Colleague,

5 Minutes of International Medicine from BMJ Group is our monthly email alerting service providing you with free access to the latest and most relevant articles from our wide range of products.

Big headed babies

Many family doctors still check child development, and may see lots of babies with a head circumference above the 99th centile. Do these babies need to be referred? This study compared head circumference according to the new UK-WHO standard with the UK 1990 reference. The UK-WHO standard identified many more infants with heads above the 98th centile, and infants with rapid head growth (defined as crossing upwards through two major centile bands) than the UK 1990 reference. Referral in these cases wouldn't be necessary.

 Source: Archives of Disease in Childhood 2011;96:386-388


Should non insulin dependent diabetics self monitor their glucose?

Anyone who uses insulin should be encouraged to use self monitoring of blood glucose (SMBG). But is it useful in diabetic patients who don't need insulin? The short answer from a systematic review is "not proven." A commentary on the review says that there is no clinically relevant benefit and that SMBG can worsen a patient's quality of life. However, there may be subgroups of patients who would benefit from SMBG; a meta-analysis is under way.

Source: Evidence Based Medicine 2011; 16:42-43

What to add to metformin?

Metformin is the first line drug for type 2 diabetes. Most patients will need additional therapy in time. Which is best? This meta-analysis shows they are similarly effective at lowering blood glucose when added to metformin. The newer therapies cause less hypoglycaemia and keep weight stable or reduce it. However, their long term effects are less well known. The options are:

*  Sulphonylureas/glinides have a risk of hypoglycaemia, but their long term effects are well documented
*  Thiazolidinediones (AGI, DPP4 inhibitors, and GLP-1 analogues)  - newer drugs with less well known long term effects but they have a lower risk of hypoglycaemia than to sulphonylureas and the glinides.
*  DPP4 inhibitors and AGI - have a neutral effect on weight
*  GLP-1 analogues - associated with highly significant weight loss.

Source: Evidence Based Medicine 2011; 16:39-40


Abdominal angina

Chronic gastrointestinal ischaemia (CGI) or abdominal angina, is more common than previously thought. Classic symptoms are
•        postprandial pain
•        weight loss due to fear of pain after eating
•        abdominal bruit on examination.
These studies showed symptoms may be more varied than this triad.  CT angiography and assessment of mucosal perfusion can help to make the diagnosis. Endovascular or surgical revascularisation can be highly successful.

Source: Gut 2011;60:722-737 doi:10.1136

______________________________________ _________________

Compiled by Dr Ann Robinson

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