[ SHOWGSD-L ] Re: So much to learn and so much to doubt
- From: "Theresa-GSD Stolz-Scenecrest Farm" <dmarc-noreply@xxxxxxxxxxxxx> (Redacted sender "scenecrest.geo@xxxxxxxxx" for DMARC)
- To: showgsd <showgsd-l@xxxxxxxxxxxxx>
- Date: Thu, 31 Jul 2014 20:14:23 -0700
I have the whole article in PDF file but can not send it here.
A de novo mutation in KIT causes white spotting in a subpopulation of German
Shepherd dogs
http://onlinelibrary.wiley.com/doi/10.1111/age.12006/abstract
Theresa
GSDCA Member
scenecrest@xxxxxxxxx
--------------------------------------------
On Thu, 7/31/14, Jen Proud <proudk911@xxxxxxxxx> wrote:
Re the pandas, since you asked (and I
don't make scientific statements
without
knowing the quote is accurate and verifiable :) quoted below
is a
summary by Dr Mark Neff at UC Davis,
who did the original mapping and
continued
research on the panda marking gene:
"A
unique coat color pattern, termed *Panda,*occurs in a single
bloodline of
German Shepherd Dogs. With the
help of the founding breeder, Ms. Cindy McCann
of Ohio, we have analyzed the DNA of Panda dogs
and their non-Panda littermates
using modern
genetic tools. We have found the following:
· The coat color pattern
stems from a spontaneous mutation; it was
not introduced from another breed or
population.
· The novel
mutation occurred in the Sire's germ line, and was then
passed down
to his daughter, who was the
only offspring of that sire to show the
distinguishing
markings.
· In subsequent generations,
the *Panda* pattern has exhibited an
autosomal dominant mode of inheritance,
consistent with the action of a
single gene
acting with full penetranpe.
· No discernible health affects have been
observed in these dogs,
though a *double
Panda* dog has not yet been produced.
As the principal investigator
of this study, I would be delighted to
answer questions
by breeders
and owners who are interested in the genetics and biology
of
this coat color pattern. I can be
contacted at:
Mark Neff,
Ph.D.
VGL Canine
Genetics
Center for
Veterinary Genetics
School
of Veterinary Medicine
University of California
mwneff@xxxxxxxxxxx
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