I knew an old time Breeder in our area many years ago that had a litter of EIGHT puppies and the entire litter had to be put down with M.E.! She had never had it before......and stubbornly repeated the breeding and did not get any!!? I understand that other Breeds have the same problem......but that it's inheritance characteristics are different in some Breeds........especially in the German Shorthair? I have been told by one Aussie breeder that their breed does not have M.E......I have been told by other Aussie people that it DEFINITELY does.......? How does it work when your stud dog has many, many, MANY litters with absolutely none......even with bitches with " the problem in the line".....inbred and outcrossed, and then all of a sudden he has a litter with 2 or 3 with someone's bitch.........?? Do you then shoot the stud and all his progeny that are already breeding? Same with a bitch ......if she has three litters with NONE.....but on the fourth litter you get 1...or 2 and yet her breeding career is pretty much over anyway......and her progeny have already been bred and so far there are none..... How do we go about eliminating what we do not know? Also....why do we always refer to the "bad" things as a recessive gene...? Why are we always so sure that it is recessive? I recall the article in the Review that suggested the possibility that only one has to be the carrier for M.E. Are we SO SURE this is not polygenetic...... ??? Sure if we KNOW the answer we can eliminate it.....but do we really know yet without DNA? AND....what else are we eliminating at the same time.......or bringing IN with each breeding. I have no answers......... Carolyn marhaven@xxxxxxx www.marhaven.com "Ok, then why did this dog produce it in one litter and not the other 4 he had? I am not sure anyone really knows it would be absolutely wonderfull if they could do a study on this problem. As least then we would know. Find the gene etc..." Deb -------------------------- I suspect there also needs to be a trigger or another gene involved. When I first started breeding GSD's I had one mega puppy in my first litter of six. My vet said he didn't know if mega was inheritable so I did breed the same parents again - twice. There were no affected puppies in a litter of 10 or the following litter of 9. Two generations later I did get one other mega puppy. This doesn't look to me like a pure recessive - I'm looking forward to the results of the genetic research into this. Most of the puppies from those litters were spayed or neutered in pet homes. Other than the bitch I kept and bred once, I only know of two others that were bred, and they didn't produce any mega in the litters they had. Janice ============================================================================ POST is Copyrighted 2006. All material remains the property of the original author and of GSD Communication, Inc. NO REPRODUCTIONS or FORWARDS of any kind are permitted without prior permission of the original author AND of the Showgsd-l Management. ALL RIGHTS RESERVED. ALL PERSONS ARE ON NOTICE THAT THE FORWARDING, REPRODUCTION OR USE IN ANY MANNER OF ANY MATERIAL WHICH APPEARS ON SHOWGSD-L WITHOUT THE EXPRESS PERMISSION OF ALL PARTIES TO THE POST AND THE LIST MANAGEMENT IS EXPRESSLY FORBIDDEN, AND IS A VIOLATION OF LAW. VIOLATORS OF THIS PROHIBITION WILL BE PROSECUTED. For assistance, please contact the List Management at admin@xxxxxxxxxxxx VISIT OUR WEBSITE - URL temporarily deleted due to AOL issues ============================================================================