[ SHOWGSD-L ] Re: Press Release re GSDs having DNA testing available for DM
- From: "Cherri Pursell" <eastgsd@xxxxxxxxxxxxx>
- To: "Seth McMullen" <mcmuse@xxxxxxx>, showgsd-l@xxxxxxxxxxxxx
- Date: Mon, 6 Dec 2004 21:39:44 -0500
I wanted to clarify something with this announcement as the announcement
really doesnt "spell it out".....basically Dr Clemmens feels he has found a
DNA marker in affected GSDs.....he is very certian but looking of course
for more samples to be positive....he is very sure.....I cannot wait for
the publication of his work and am amazed that he was able to do this in
the time he has been researching this disease.....the stem cell research
will go on I believe as a possible treatment situation....so there are two
subjects in the announcement basically.....1. Dr C wants samples from
affected dogs to clarify his findings (the DNA marker) (Yiiiiippppeeee!!!
wow!!) and 2. Dr C still needs our support with donations to try to
research a treatment....
With the finding of a DNA marker comes the ability to test our stock of
course for the presence of the gene/s <VBS> It also provides a clue to
causation and treatment :)
Here is Marj's page about donations for Dr C and information on test
samples etc...
http://www.mzjf.com/dmdonation.htm
Its a very happy holiday season for Marj......
Cherri Pursell
eastgsd@xxxxxxxxxxxxx
Thom's GSDs NJ
www.eastgsd.com
> [Original Message]
> From: Seth McMullen <mcmuse@xxxxxxx>
> To: <showgsd-l@xxxxxxxxxxxxx>
> Date: 12/6/2004 4:06:25 PM
> Subject: [ SHOWGSD-L ] FW: Press Release re GSDs having DNA testing
available for DM
>
> >I received this email from the mail list of my local all breed club. I
> >thought I would forward it if anyone is interested!
>
> Hallie
>
>
> >Breaking DM News!!!!
> >
> >
> >
> > December 2004
> >
> >Dr. Clemmons is now able to accept samples for DNA evaluation, at least
in
> >suspect affected GSDM dogs. He can run the test for people, knowing that
it
> >may be negative in a number of suspect cases. However, he cannot run it
for
> >free since the reagent cost is currently high. Therefore, he is asking
> >people to make a $50.00 donation to the University of Florida Foundation
> >with 'for Dr. Clemmonsâ?? research' in the memo section and to send the
> >check along with the CBC sample on a cold pack to him, overnight
delivery.
> >Your local veterinarian may be able to help you with this. Dr Clemmons
will
> >provide the results within 2 weeks. He still feels it should not be the
> >sole diagnostic run for the disease, but it may go a long way toward
> >confirming the presence of GSDM.
> >
> >Dr Clemmons is hoping that he will be able to start stem cell
> >transplantation of bone marrow-derived mesenchymal stem cells early next
> >year. There are several cases with whom he is talking. He may not be
able
> >to do this for free either without additional funding, but it is
probably
> >too important to wait for the funding. Sadly, there is not tons of money
> >laying around to subsidize the work. Dr Clemmons believes he can
determine
> >safety (certainly should be from all the available human data) and may
be
> >able to get some idea about efficacy. Unfortunately, he canâ??t track
the
> >cells or prove he has fixed anything unless the MRI data is superb. He
> >might get some answers down the line, but he does not want to use vector
> >infected cells in patients until he knows for sure the vector wonâ??t
cause
> >problems down the line. Of course, that only helps you if you do
necropsies
> >on the patients, too. His hope is that the stem cells will fix the dogs
and
> >necropsies will be a long time off. So, we are pretty excited.
> >
> >The stem cells take a couple of appointments and Dr Clemmons will look
to
> >use it in more advanced cases (where the current medication arenâ??t
> >working, yet he have confirmed the GSDM as the sole cause) initially.
The
> >first appointment is to make sure of the Dx and to collect the bone
marrow.
> >The bone marrow stem cells will be cultured and, if all goes well, then
> >replaced in the patient (but in the CSF space) in about 3 weeks. He will
> >then have to monitor and see how thing go. Some of this will be just
> >observation, but EMG data will help determine if he has changed things.
So,
> >it may require a follow-up visit 2 months after transplantation. All in
all
> >it will be fairly involved and he will have to be in close touch with
the
> >owners. It is also something he wouldnt be able to do without seeing the
> >patients. So, the owners have to be committed and also have to have the
> >financial resources to be able to do it. He will subsidize what he can,
but
> >he needs to be offering the best he knows. He can offer his skill and
> >compassion. That he will provide for free. He wonâ??t charge for doing
the
> >bone marrow, but may for the tests to be sure it is the right thing and
for
> >the implantation and hospitalization. That is not small, but still a lot
of
> >savings.
> >
> >Dr Clemmons canâ??t help everyone and he will have to be fairly
selective
> >on the imaging and stem cell studies for the moment, but the flood gates
> >are open for sampling the DNA. If he can eventually control the costs
(by
> >volume) he might be able to use any remainder of money to help defray
the
> >costs for the stem cells. If you have a German Shepherd Dog that your
vet
> >feels may have Degenerative Myelopathy, and you wish to send a DNA
sample,
> >it is best to send a CBC tube on a refrigerator pack (not frozen) over
> >night express to:
> >
> >R.M. Clemmons, DVM, PhD
> >Associate Professor of Neurology & Neurosurgery
> >SACS, College of Veterinary Medicine
> >Box 100126, HSC
> >2015 SW 16th Avenue, V2-107
> >University of Florida
> >Gainesville, FL 32610-0126
> >
> >
> >352.392.4700
> >
> >
>
>
>
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POST is Copyrighted 2004. All material remains the property of the original
author and of GSD Communication, Inc. NO REPRODUCTIONS or FORWARDS of any kind
are permitted without prior permission of the original author AND of the
Showgsd-l Management. ALL RIGHTS RESERVED.
ALL PERSONS ARE ON NOTICE THAT THE FORWARDING, REPRODUCTION OR USE IN ANY
MANNER OF ANY MATERIAL WHICH APPEARS ON SHOWGSD-L WITHOUT THE EXPRESS
PERMISSION OF ALL PARTIES TO THE POST AND THE LIST MANAGEMENT IS EXPRESSLY
FORBIDDEN, AND IS A VIOLATION OF LAW. VIOLATORS OF THIS PROHIBITION WILL BE
PROSECUTED.
For assistance, please contact the List Management at admin@xxxxxxxxxxxx
VISIT OUR WEBSITE - http://www.showgsd.org
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