[ SHOWGSD-L ] MU study shows promise for early detection of OA in dogs

From: Stormy Hope <Stormy435@xxxxxxx>
To: freelist <showgsd-l@xxxxxxxxxxxxx>
Date: Tue, 16 Jun 2009 08:52:12 -0700
MU study shows promise for early detection of OA in dogs
Jun 15, 2009
DVM NEWSMAGAZINE
_http://veterinarynews.dvm360.com/dvm/Veterinary+news/MU-study-shows-promise
-for-early-detection-of-OA-i/ArticleStandard/Article/detail/603755? 
contextCa
tegoryId=378_
(http://veterinarynews.dvm360.com/dvm/Veterinary+news/MU-study-shows-promise-for-early-detection-of-OA-i/ArticleStandard/Article/detail/60
3755?contextCategoryId=378)

Columbia, Mo. -- In a study that could have applications in human  
medicine
as well, researchers at the University of Missouri are studying  
potential
biomarkers in dogs that could lead to early diagnosis of osteoarthritis
(OA), helping identify patients at higher risk for the disease.
Because OA is most often diagnosed in later, irreversible stages,  
treatment
usually is limited to slowing disease progress and decreasing pain. "By
developing methods for earlier diagnosis, prevention or even curative
treatment strategies ... become more realistic," says James Cook,  
professor of
veterinary medicine and surgery at MU. "Biomarkers could detect the  
disease
before pain and swelling occurs, and owners could take preventive  
measures,
such as modifying the pet's activities or diet, helping them lose  
weight and
strengthening their joints."
The MU research team examined possible biomarkers in joint-lubricating
synovial fluid because it is known to respond to joint injury. Samples  
taken
from dogs showed that synovial fluid quality and quantity were altered  
in
injured stifle joints.
"Our team ... is making progress in developing simple tests on blood,  
urine
and synoval fluid that show great promise for helping us diagnose
impending OA before it is too late," Cook says.
Some 20 percent of middle-aged dogs and 90 percent of older dogs have  
OA in
one or more joints, and the disease is equally common in humans and
horses.
The MU study, titled "Examination of Synovial Fluid Hyaluronan  
Quantity and
Quality in Stifle Joints of Dogs with Osteoarthritis," was published in
the American Journal of Veterinary Research. Co-authors are Cook, Rachel
Venable, doctoral student; Aaron Stoker, assistant professor; Cristi  
Cook,
clinical assistant professor; and Mary Cockrell, research specialist.

Related Links _Canine
osteoarthritis: understanding the etiology, clinical presentation and  
diagnosis_
(http://veterinarynews.dvm360.com/dvm/Veterinary+Medicine:+Clinical+Edge/Canine
-Osteoarthritis-Understanding-the-etiology-c/ArticleStandard/Article/ 
detail/
183287)


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[ SHOWGSD-L ] MU study shows promise for early detection of OA in dogs

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