[ SHOWGSD-L ] Re: DM DNA test - question
- From: Louise Cauthen <cauthenl@xxxxxxxxx>
- To: Ginialtman@xxxxxxx
- Date: Tue, 21 Apr 2009 08:23:28 -0700 (PDT)
Thanks for this information Ginny.
My dogs were all tested negative for the GSD DM Flash Test already [some
individually and some as part of the studies] - so - are you saying that these
dogs *could* be now tested with the *new* DM test for another *type* of DM?
Has this other *type* of DM [the Corgi and or Boxer type?] been found /
diagnosed / proved to *be* in GSDs?
Thanks for keeping up with all of this for us! It can be confusing!
Louise
--- On Mon, 4/20/09, Ginialtman@xxxxxxx <Ginialtman@xxxxxxx> wrote:
From: Ginialtman@xxxxxxx <Ginialtman@xxxxxxx>
Subject: [ SHOWGSD-L ] DM DNA test
To: showgsd-l@xxxxxxxxxxxxx
Date: Monday, April 20, 2009, 6:19 PM
I would like to urge our members to please get the U of Florida Flash test
as well as the OFA test. It will go a long way in helping us to
understand the Disease of DM in German Shepherd Dogs. The Flash test will be
available again in a three or four weeks --Dr Clemmons had a physical move of
his
lab within the U of FLa -- anyway --We GSD owners and breeders need both
of these tests because while the Flash test is in GSD (and not in the Corgi)
it is in the DNA location for human Multiple Sclerosis. The OFA test was
discovered in the Corgi --has been found to be present in the GSD but is in
the DNA location for ALS or Lou Gehrigs disease in humans. The full
picture of what we know as DM is not yet known and the evidence obtained by
the
standard diagnostic tests for GSDM and tissue pathology points to the
disease in GSD being Multiple Sclerosis--specifically Primary Progressive
Multiple Sclerosis. Please, if you would be willing to do the tests--do both
OFA and U of Fla Flash test. Contact me -- I will get the link for the U of
Florida to you. The Breed Thanks You and so do I.
Ginny Altman, GSDCA Health and Genetics Chair
From: "Peter Cacioppo" <petercacioppo@xxxxxxxxxxxxxxxxxx>
Subject: OFA's new DM Gene Marker Test
Date: Mon, 20 Apr 2009 09:01:46 -0700
Previous e-mail FROM REBECCA:
From: "Rebecca Little" <pbgs@xxxxxxxxxxxx>
Subject: DM DNA test from OFA
Has anyone on the list used the DM test from OFA? I just ordered one and
will do the rest of my gang over time(its $65 per test). Just wondering
what
everyone thought of the test.
Rebecca Little
My ANSWER:
Yes, used it on Cab and got a great result for him.
Eagle Hill's Cabernet Sauvignon
( "Cab" or "Cabernet")AKC DN11042402.
Cab has his permanent OFA Hip and Elbow Certification: Hips Good and Elbows
Normal, received on June 1, 2007: GS-76443G24M-PI (micro-chip);
GS-EL20512M24-PI. Cab also received a Normal/Normal on his two OFA DM
markers, received March 31, 2009; GS-DM132/46M-PI.
I ran Cab through the OFA test for DM (this is the University of
Missouri's
test) Remember they test something different than the University of
Florida
researchers apparently. It is said that the University of Missouri people
think DM is related to the L. Gehrig disease, and the University of Florida
is saying GSDM is like the human Multiple Sclerosis ("MS") disease.
Anyway, the OFA test is showing Cab has two normal genes. (I believe it is
like "coats", where a puppy gets one gene from the sire and one gene
from
the dam. Thus, a puppy could be a "carrier" on DM by getting one
defective
gene from the dam and one normal gene from the sire.....or the puppy could
be at risk, by getting two defective genes, one from each parent.... or two
normal genes, like Cab). Thus a sire like Cab can only give a normal gene
when he is bred. If the dam also has two normal genes, then each puppy
resulting can only have two normal genes.
You order the DM testing kit from the OFA site.
It is a simple swab from inside of the mouth and results came back in only
3
weeks.
Peter Cacioppo
www.EagleHillGroup.net
Eagle Hill Wines and Vineyards, Moraga, CA
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POST is Copyrighted 2008. All material remains the property of the original
author and of GSD Communication, Inc. NO REPRODUCTIONS or FORWARDS of any kind
are permitted without prior permission of the original author AND of the
Showgsd-l Management. ALL RIGHTS RESERVED.
ALL PERSONS ARE ON NOTICE THAT THE FORWARDING, REPRODUCTION OR USE IN ANY
MANNER OF ANY MATERIAL WHICH APPEARS ON SHOWGSD-L WITHOUT THE EXPRESS
PERMISSION OF ALL PARTIES TO THE POST AND THE LIST MANAGEMENT IS EXPRESSLY
FORBIDDEN, AND IS A VIOLATION OF LAW. VIOLATORS OF THIS PROHIBITION WILL BE
PROSECUTED.
For assistance, please contact the List Management at admin@xxxxxxxxxxxx
VISIT OUR WEBSITE - http://showgsd.org
NATIONAL BLOG - http://gsdnational.blogspot.com/
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