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*Dagens forskningsoversigt fra Scias Update:*
All-cause and cause-specific mortality rates of patients treated for
alcohol use disorders: A meta-analysis.
Subst Abus. 2018;39(4):509-517
Authors: Abdul-Rahman AK, Card TR, Grainge MJ, Fleming KM
Abstract
BACKGROUND: Although alcohol use disorders (AUDs) are known to increase the
relative risk of all-cause and some cause-specific mortality, the absolute
mortality rates of the AUD population are unknown. Such knowledge would
benefit planners of the provision of services for this population,
including in prioritizing the identification and/or treatment of diseases
likely to cause their death.
METHODS: We conducted a systematic review of studies in English, reporting
the cause-specific mortality rates among people treated for AUDs. Number of
deaths by cause and total person-years of follow-up were extracted.
All-cause and cause-specific mortality rates per 1000 person-years were
meta-analyzed assuming random effects.
RESULTS: Thirty-one studies were included. Participants were mainly
middle-aged males. The quality of studies was generally good. A total of
6768 all-cause deaths in 276,990.7 person-years of follow-up (36,375
patients) were recorded, and the pooled all-cause mortality rate was
27.67/1000 person-years (py) (95% confidence interval [CI]: 23.9, 32.04).
The most common cause of death in the AUD population was cardiovascular
disease (CVD) (6.9/1000 py; 95% CI: 5.61, 8.49), followed by
gastrointestinal deaths (5.63/1000 py; 95% CI: 4.1, 7.74), unnatural deaths
(4.95/1000 py; 95% CI: 4.01, 6.09)), neoplasms, respiratory diseases, and
substance use disorders.
CONCLUSIONS: Patients with AUDs have increased rates of all-cause and
cause-specific mortality compared with the general population. Like the
general population, they are most likely to die of CVD. In contrast to the
general population, gastrointestinal and unnatural deaths are the next most
common causes of death. We believe these facts should be considered when
planning health care services for patients with AUDs.
PMID: 29958085
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Dette abstract er hentet via PubMed fra National Library of Medicine, USA
<https://www.ncbi.nlm.nih.gov/home/about/policies>.
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Du kan også finde ovenstående abstract på *Facebook*
<https://evidens.link/2PGdi81> eller *PubMed* <https://fsv.link/32v2qvo>.
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