[net-gold] MEDICAL: HEART AND CARDIOVASCULAR: BLOOD PRESSURE: NIH-Supported Study Finds Novel Pathway May Open Doors for New Blood Pressure Treatments
- From: "David P. Dillard" <jwne@xxxxxxxxxx>
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- Date: Sun, 26 Sep 2010 21:02:10 -0400 (EDT)
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MEDICAL: HEART AND CARDIOVASCULAR: BLOOD PRESSURE:
NIH-Supported Study Finds Novel Pathway
May Open Doors for New Blood Pressure Treatments
Date: Tue, 22 Jun 2010 09:07:09 -0400
From: "NIH OLIB (NIH/OD)" <olib@xxxxxxxxxx>
To: NIHPRESS@xxxxxxxxxxxx
Subject: NIH-Supported Study Finds Novel Pathway
May Open Doors for New Blood Pressure Treatments
U.S. Department of Health and Human Services
NATIONAL INSTITUTES OF HEALTH NIH News
National Institute of Environmental Health Sciences (NIEHS)
http://www.niehs.nih.gov/
For Immediate Release: Monday, June 21, 2010
CONTACT:
Robin Mackar, NIEHS
919-541-0073
e-mail:
rmackar@xxxxxxxxxxxxx
NIH-SUPPORTED STUDY FINDS NOVEL PATHWAY
MAY OPEN DOORS FOR NEW BLOOD PRESSURE TREATMENTS
Researchers have found that increasing certain proteins in the blood
vessels of mice, relaxed the vessels, lowering the animal's blood
pressure. The study provides new avenues for research that may lead to new
treatments for hypertension.
"The paper demonstrates that cytochrome P450 plays an important role in
the management of high blood pressure, a disease of enormous public health
concern," said Darryl Zeldin, M.D., acting clinical director of the
National Institute of Environmental Health Sciences (NIEHS) and senior
author on the paper.
According to the Centers for Disease Control and Prevention, about 1 in 3
adults in the United States has high blood pressure, which increases the
risk for heart disease and stroke, the first and third leading causes of
death in the United States.
The study, published online in The FASEB Journal, was conducted by
researchers at NIEHS who teamed with investigators at the University of
North Carolina at Chapel Hill (UNC), Medical College of Wisconsin,
Milwaukee, and Oregon Health and Science University, Portland.
The researchers created animal models that had a human cytochrome P450
(CYP450 or P450) in the cells that line their blood vessels. The mice with
the P450 generated more substances called epoxyeicosatrienoic acids or
EETs, known for their role in protecting the cardiovascular system. EETs
relax and dilate the blood vessels and fight inflammation.
"We found that when the animals were exposed to substances known to
increase blood pressure, the animals with the P450 had lower blood
pressure and less damage to the kidneys compared to normal mice," said
Craig R. Lee, Pharm.D., Ph.D., assistant professor at UNC and lead author
on the paper. "We hope that these studies will advance the development of
new treatments for high blood pressure."
"This is a great example of a basic finding that improves our
understanding of a metabolic pathway that can be used to develop improved
treatments for those suffering from a common disease like hypertension,"
said Linda Birnbaum, Ph.D., director of the NIEHS and the National
Toxicology Program.
For more information on hypertension, visit
http://www.nhlbi.nih.gov/health/dci/Diseases/Hbp/HBP_WhatIs.html
The NIEHS supports research to understand the effects of the environment
on human health and is part of NIH. For more information on environmental
health topics, visit our Web site at <http://www.niehs.nih.gov>. Subscribe
to one or more of the NIEHS news lists
http://www.niehs.nih.gov/news/releases/newslist/index.cfm
to stay current on NIEHS news, press releases, grant opportunities,
training, events, and publications.
The National Institutes of Health (NIH) -- The Nation's Medical Research
Agency -- includes 27 Institutes and Centers and is a component of the
U.S. Department of Health and Human Services. It is the primary federal
agency for conducting and supporting basic, clinical and translational
medical research, and it investigates the causes, treatments, and cures
for both common and rare diseases. For more information about NIH and its
programs, visit
http://www.nih.gov
-----------------------
REFERENCE: Lee CR, Imig JD, Edin ML, Foley J, DeGraff LM, Bradbury JA, et
al. 2010. Endothelial expression of human cytochrome P450 epoxygenases
lowers blood pressure and attenuates hypertension-induced renal injury in
mice. FASEB J. Epub ahead of print 2010 May 21, doi:10.1096/fj.10-160119.
##
This NIH News Release is available online at:
http://www.nih.gov/news/health/jun2010/niehs-21.htm
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Temple University
(215) 204 - 4584
jwne@xxxxxxxxxx
http://daviddillard.businesscard2.com
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