Have you looked in the JAWS options dialog to see how you have your "edge of Data Regions" set, or whether you have single or multiple regions set? I'm no expert on this, but play around with the settings to see if you get the results you expect. Dave ----- Original Message ----- From: Godwin Adoyi To: jfw@xxxxxxxxxxxxx Sent: Thursday, January 07, 2010 09:40 Subject: Navigating in Microsoft excel 2003 Hello, I use to navigate to end of region of a work book with control plus the arrow keys but can't do that now. Control plus left arrow works but control plus arrow up, down and right don't work. Can any one assist? Best regards, Godwin Adoyi