Hi List: First of all, 64 bit computer systems will run 32 bit applications. In fact a lot of computers sold now a days are 64 bit hardware running all 32 bit software, because of the lack of many 64 bit applications. Secondly, according to a computer magazine article I read recently, Window Vista is screen reader compatible. If I understood it correctly, you will have to run Windows Vista in windows XP/98 classic mode, and not the new GUI, (graphical user interface) mode. I hope this helps! P.S. I'm sorry! I don't remember where the article was. Wayne