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Dagens #fsvoversigt:
Genetic variations underlying self-reported physical functioning: a review.
Qual Life Res. 2015 May;24(5):1163-77
Authors: Thong MS, Sprangers MA, Sloan JA, Patrick DL, Yang P, van Noorden CJ
Abstract
PURPOSE: Genetic associations with self-reported physical functioning (SPF) are
less well-studied than genetic associations with performance-measured physical
functioning (PPF). We review the literature on the associations of genetic
variations on SPF. We provide an overview of SPF assessment, genetic
contributions to SPF including heritability, effects of genetic variations and
mutations, and effects of interventions on the gene-SPF relationship. We also
aim to provide directions for future research.
METHODS: A computerized literature search using PubMed, Web of Science, and
PsychInfo was conducted to select relevant literature published up to November
2013. Inclusion criteria were the use of an SPF questionnaire, original
articles in English on human subjects, published in peer-reviewed journals and
reporting significant associations between SPF and the genome.
RESULTS: Nineteen articles were included. SPF was commonly assessed with the
Short Form-36 questionnaire involving mainly convenience samples of either
older persons or chronically ill. Heritability estimates were 10-30 %.
Candidate genes associated with SPF could be ascribed to biological pathways
associated with neurodegeneration, physiological systems regulation, or cell
regulation. The APOE gene associated with neurodegeneration was most studied (n
= 3). Three papers included both SPF and PPF assessments. No genome-wide
association study on SPF has been conducted.
CONCLUSIONS: Associations between SPF and the genome have been investigated in
selected populations in a limited number of publications. Future research
should consider increasing sample variation and incorporate both SPF and PPF
assessments. Also, longitudinal studies should be conducted in order to elicit
stronger conclusions regarding the genetic associations with SPF.
PMID: 25387867 [PubMed - indexed for MEDLINE]
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Dette abstract er hentet via PubMed fra National Library of Medicine, USA
(http://www.ncbi.nlm.nih.gov/About/disclaimer.html).
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