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Dagens #fsvoversigt:
A systematic review and meta-analysis of physical activity and endometrial
cancer risk.
Eur J Epidemiol. 2015 May;30(5):397-412
Authors: Schmid D, Behrens G, Keimling M, Jochem C, Ricci C, Leitzmann M
Abstract
Physical activity is related to decreased endometrial cancer risk. However, a
comprehensive investigation of activity domains, intensities, time periods in
life, and potential interaction with body mass index is unavailable. We
performed a meta-analysis of physical activity and endometrial cancer studies
published through October 2014. We identified 33 eligible studies comprising
19,558 endometrial cancer cases. High versus low physical activity was related
to reduced endometrial cancer risk [relative risk (RR) = 0.80; 95% confidence
interval (CI) 0.75-0.85]. The corresponding RRs for recreational activity,
occupational activity, household activity, and walking were 0.84 (95% CI
0.78-0.91), 0.81 (95% CI 0.75-0.87), 0.70 (95% CI 0.47-1.02), and 0.82 (95% CI
0.69-0.97), respectively (Pdifference). Walking/biking for transportation,
walking for recreation, and walking without specification revealed summary RRs
of 0.70 (95% CI 0.58-0.85), 0.94 (95% CI 0.76-1.17), and 0.88 (95% CI
0.52-1.50), respectively (Pdifference). Inverse associations were noted for
light (RR 0.65; 95% CI 0.49-0.86), moderate to vigorous (RR 0.83; 95 % CI
0.71-0.96), and vigorous activity (RR 0.80; 95% CI 0.72-0.90; (Pdifference). A
statistically significant inverse relation was found for postmenopausal (RR
0.81; 95% CI 0.67-0.97), but not premenopausal women (RR 0.74; 95% CI
0.49-1.13; (Pdifference). Physical activity performed during
childhood/adolescence, young adulthood/midlife, and older age yielded RRs of
0.94 (95% CI 0.82-1.08), 0.77 (95% CI 0.58-1.01), and 0.69 (95% CI 0.37-1.28),
respectively (Pdifference). An inverse relation was evident in overweight/obese
(RR 0.69; 95% CI 0.52-0.91), but not normal weight women (RR 0.97; 95% CI
0.84-1.13; (Pdifference). In conclusion, recreational physical activity,
occupational physical activity, and walking/biking for transportation are
related to decreased endometrial cancer risk. Inverse associations are evident
for physical act
ivity of light, moderate to vigorous, and vigorous intensities. The inverse
relation with physical activity is limited to women who are overweight or obese.
PMID: 25800123 [PubMed - indexed for MEDLINE]
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Dette abstract er hentet via PubMed fra National Library of Medicine, USA
(http://www.ncbi.nlm.nih.gov/About/disclaimer.html).
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Se abstractet i PubMed: http://evidens.link/1Ppb4S8
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adgang til artikler på http://www.fsvoversigter.dk.
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