Some of you may be interested in this upcoming webinar.
[Webinar: HCS for Predictive Toxicology and in vitro Pathology Using Simple 3D
Microtissues]
Webinar: HCS for Predictive Toxicology and in vitro Pathology Using Simple 3D
Microtissues
Wednesday, 6 September 2017
8am PDT / 11am EDT / 4pm BST / 5pm CEST
[Register
Now]<http://app.info.perkinelmer.com/e/er?utm_campaign=LST-Toxicology-GLO-2017-Q3-Email-EPKI-Webinar&utm_medium=email&utm_source=Eloqua&s=1674556495&lid=6663&elqTrackId=383e24c473c94b22b12c7ba333712b78&elq=bacadb973f8d4d4a9c27fc013c45f358&elqaid=4969&elqat=1>
This webinar will describe the integration of biology and engineering to devise
simple, high-throughput 3D human microtissues as predictive biology platforms
that reflect human physiology and disease, solving fundamental questions of
adverse biological response with the goal of modernizing toxicity and drug
candidate testing.
A key aspect of this approach is the implementation of "in vitro pathology",
making use of quantitative metrics from reconstructed 3D microtissue images to
discern adverse biological effects. This strategy is currently being used to
develop 3D microtissues of a variety of human tissues, exploring the utility of
single cell lines, co-cultures of cells, and human induced pluripotent stem
cells. The goal is to access a wide variety of cellular behavior,
characterizing responses across the biological landscape using simple and rapid
techniques.
Learning outcomes
· The tension between assay simplicity and biological complexity in
designing 3D microtissues
· Development of a human breast cancer MCF-7 3D microtissue model as an
initial example of the approach
· The definition of in vitro pathology and its application in
quantifying the effects of estrogenic exposures in the MCF-7 3D microtissue
model
· Challenges and opportunities that arise with primary cells,
co-cultures, and induced pluripotent stem cells
Speakers
[Kim Boekelheide]
Kim Boekelheide, M.D., Ph.D.
Professor of Pathology and Laboratory Medicine, Brown University School of
Medicine
[Joe Trask]
Joe Trask
Senior Field Applications Scientist, PerkinElmer
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