EPA Releases Guidance on a Voluntary Pilot Program to Reduce Animal Testing
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EPA is announcing the start of a voluntary pilot program to evaluate the
usefulness and acceptability of a mathematical tool that estimates the
toxicological classification of a chemical, which is used in theGlobally
Harmonized System of Classification and Labeling of
Chemicals<http://links.govdelivery.com:80/track?type=click&enid=ZWFzPTEmbXNpZD0mYXVpZD0mbWFpbGluZ2lkPTIwMTYxMjIwLjY3OTA4MTAxJm1lc3NhZ2VpZD1NREItUFJELUJVTC0yMDE2MTIyMC42NzkwODEwMSZkYXRhYmFzZWlkPTEwMDEmc2VyaWFsPTE2OTgwMzc5JmVtYWlsaWQ9a3N1bGxpdmFuQHBjcm0ub3JnJnVzZXJpZD1rc3VsbGl2YW5AcGNybS5vcmcmdGFyZ2V0aWQ9JmZsPSZtdmlkPSZleHRyYT0mJiY=&&&101&&&https://www.epa.gov/pesticide-labels/pesticide-labels-and-ghs-comparison-and-samples>
(GHS) and which is referred to as the GHS Mixtures Equation. This mathematical
tool can be used as an alternative to acute animal oral and inhalation toxicity
studies for pesticide formulations. EPA is now providing guidance on how
pesticide companies can voluntarily submit data for the GHS Mixtures Equation
Pilot Program.
EPA is requesting submission of acute oral and acute inhalation toxicity study
data paired with mathematical calculations (GHS Mixtures Equation data) to
support the evaluation of pesticide product formulations. Registrants and
applicants for registration interested in providing data to the Agency should
follow the instructions on the GHS Equation Pilot Program
webpage<http://links.govdelivery.com:80/track?type=click&enid=ZWFzPTEmbXNpZD0mYXVpZD0mbWFpbGluZ2lkPTIwMTYxMjIwLjY3OTA4MTAxJm1lc3NhZ2VpZD1NREItUFJELUJVTC0yMDE2MTIyMC42NzkwODEwMSZkYXRhYmFzZWlkPTEwMDEmc2VyaWFsPTE2OTgwMzc5JmVtYWlsaWQ9a3N1bGxpdmFuQHBjcm0ub3JnJnVzZXJpZD1rc3VsbGl2YW5AcGNybS5vcmcmdGFyZ2V0aWQ9JmZsPSZtdmlkPSZleHRyYT0mJiY=&&&102&&&https://www.epa.gov/pesticide-registration/mixtures-equation-pilot-program-reduce-animal-testing>.
We anticipate that the pilot will run for approximately six months; however,
if we receive sufficient data before the six months are up, we will begin our
analysis earlier.
The start of this GHS pilot program is another step toward EPA’s goal of
reducing animal testing by adopting better testing methods as described in the
Office of Pesticide Programs Director Jack Housenger letter to
stakeholders<http://links.govdelivery.com:80/track?type=click&enid=ZWFzPTEmbXNpZD0mYXVpZD0mbWFpbGluZ2lkPTIwMTYxMjIwLjY3OTA4MTAxJm1lc3NhZ2VpZD1NREItUFJELUJVTC0yMDE2MTIyMC42NzkwODEwMSZkYXRhYmFzZWlkPTEwMDEmc2VyaWFsPTE2OTgwMzc5JmVtYWlsaWQ9a3N1bGxpdmFuQHBjcm0ub3JnJnVzZXJpZD1rc3VsbGl2YW5AcGNybS5vcmcmdGFyZ2V0aWQ9JmZsPSZtdmlkPSZleHRyYT0mJiY=&&&103&&&https://www.regulations.gov/document?D=EPA-HQ-OPP-2016-0093-0003>.
