I apologize for the short notice, but ASCCT member Tom Knudsen is giving a
seminar, available in person or over the web, on computational modeling and
developmental toxicity. Information follows:
_____________________________________________________________
TITLE: Computational Modeling and Simulation of Developmental Toxicity
Instructor: Thomas B. Knudsen, PhD
Developmental Systems Biologist
National Center for Computational Toxicology
US EPA/ORD
Date: December 2, 2016
10:00 am - 2:00 pm
University Station Room 2068 (limited seating) and Webinar
College Park MD- Right across from the College Park Metro
SYNOPSIS: The question of how tissues and organs are shaped during development
is crucial for understanding human birth defects. Data from high-throughput
screening assays on human stem cells may be utilized predict developmental
toxicity with reasonable accuracy. Other types of models are necessary,
however, for mechanism-specific analysis because embryogenesis requires precise
timing and control. Agent-based modeling and simulation (ABMS) is an approach
to virtually reconstruct these dynamics, cell-by-cell and
interaction-by-interaction. Using ABMS, HTS lesions from ToxCast can be
integrated with patterning systems heuristically to propagate key events over
time thereby providing an in silico platform to model developmental toxicity
from fundamental cell and molecular bioactivity data.
Topic: Computational Modeling and Simulation of Developmental Toxicity
Date: Friday, December 2, 2016
Time: 10:00 am, Eastern Standard Time (New York, GMT-05:00)
Meeting Number: 740 792 331
Meeting Password: 112233
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