For your interest, Marcel Begin doorgestuurd bericht: Van: "Bredenoord, A.L." <A.L.Bredenoord@xxxxxxxxxxxxx<mailto:A.L.Bredenoord@xxxxxxxxxxxxx>> Onderwerp: [Ethiek-mailinglist-VvEN] Job vacancy - PhD student “Ethics of pluripotent stem cell research: moving stem cells to the clinic” Datum: 16 oktober 2012 11:21:28 CEST Aan: "Ethiek-mailinglist-VvEN@xxxxxxxxxxxxxxxx<mailto:Ethiek-mailinglist-VvEN@xxxxxxxxxxxxxxxx>" <Ethiek-mailinglist-VvEN@xxxxxxxxxxxxxxxx<mailto:Ethiek-mailinglist-VvEN@xxxxxxxxxxxxxxxx>> Antwoord aan: <A.L.Bredenoord@xxxxxxxxxxxxx<mailto:A.L.Bredenoord@xxxxxxxxxxxxx>> Please circulate in your network! PhD student “Ethics of pluripotent stem cell research: moving stem cells to the clinic” Your profile In this 3-year project you will write a PhD-thesis on the ethics of translating basic (pluripotent) stem cell research into cell-based interventions. You have a Master in Medicine, Life Sciences, Philosophy and/or (Bio)ethics. A demonstrable interest in biomedical research ethics and/or (the ethics of) regenerative medicine and stem cells is an advantage. In our project we will combine normative analysis with semi-structured interviews. Therefore, experience with ethics research and/or empirical research methodology will be considered an advantage as well.You should be able to grasp both the technical background of (pluripotent) stem cells as well as to conduct theoretical ethical analysis. You are highly motivated, skilled in interdisciplinary team work, but also able to work independently. You are prepared to travel within the Netherlands and abroad in order to conduct the interviews. You have fluent oral and writing communication skills in English and preferably also in Dutch. The project Pluripotent stem cells (PSCs) are capable of self-renewal and have the capacity to differentiate into any cell type of the human body. Two types of PSCs exist: human embryonic stem cells and induced pluripotent stem cells. PSC research has great potential for regenerative medicine, which is an umbrella term for a set of innovative approaches to the treatment of illness, injury and disability, focusing on the growth, replacement and repair of cells, organs and tissues. It at the same time is accompanied by a fierce ethical and political debate. In this project we will examine whether and how we can ethically justify and launch early-phase pluripotent stem cell trials. The inherent uncertainty of first-in-human trials combined with the technical complexity of PSCs make early-phase PSC trials ethically very challenging. What value of first-in-human trials can justify the risks and burden for research participants? We will ethically evaluate both the ethical issues raised in the preclinical phase (e.g. the establishment and governance of stem cell banks, the source of different type of cells, the creation of chimaeras and admixed embryos) as well as the ethical issues associated with launching an early clinical trial (e.g. risk-benefit assessment, the concept of ‘value’ in translational research, participant selection). Your position You will work in the Department of Medical Humanities of the Julius Center of the University Medical Center Utrecht. Supervisors of this project will be prof dr JJM van Delden and dr AL Bredenoord. We will closely cooperate with researchers from the strategic program of Regenerative Medicine and Stem Cells of the UMC Utrecht. You will write a PhD thesis (based on scientific publications) and follow courses of the Graduate School of Life Sciences and/or Ethics, and also give courses on Medical Ethics at the Faculty of Medicine. More information on this project can be obtained by dr AL Bredenoord a.l.bredenoord@xxxxxxxxxxxxx<mailto:a.l.bredenoord@xxxxxxxxxxxxx> / +31(0)88-7551351. Please send your application to dr AL Bredenoord with reference to vacancy number 2012/0518. Starting date: January 1, 2013. Please reply before November, 14th. Interviews will take place on wednesday November 21st. The maximum monthly salary for this 100% position is €2673.00 gross on the basis of full-time employment (working week of 36 hours). This is a temporary appointment for 3 years. Dr A.L. Bredenoord Assistant Professor of Medical Ethics Division Julius Center, Medical Ethics, UMC Utrecht Tel + (0)88 755 1351 / +31 (0)6 4107 4365 A.L.Bredenoord@xxxxxxxxxxxxx<mailto:A.L.Bredenoord@xxxxxxxxxxxxx> Visiting address: Stratenum, room 5.135 Heidelberglaan 100, 3584 CX Utrecht, The Netherlands Postal address: Huispostnummer Stratenum 6.131 PO Box 85500, 3508 GA Utrecht, The Netherlands www.umcutrecht.nl http://people.juliuscentrum.nl/profile.aspx?id=32123 ________________________________ De informatie opgenomen in dit bericht kan vertrouwelijk zijn en is uitsluitend bestemd voor de geadresseerde. Indien u dit bericht onterecht ontvangt, wordt u verzocht de inhoud niet te gebruiken en de afzender direct te informeren door het bericht te retourneren. Het Universitair Medisch Centrum Utrecht is een publiekrechtelijke rechtspersoon in de zin van de W.H.W. 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