Advancing non-animal testing methods: first set of novel knowledge tools
published<http://alttox.org/advancing-non-animal-testing-methods-first-set-of-novel-knowledge-tools-published/>
Catherine Willet, HSUS From the European Commission: The Organisation for
Economic Co-operation and Development (OECD) has recently published the first
five adverse outcome pathways (AOP), three of which have been developed by the
JRC. The AOPs are novel knowledge management tools in toxicology and are useful
for supporting risk assessment to human health. They are […]Read
More<http://alttox.org/advancing-non-animal-testing-methods-first-set-of-novel-knowledge-tools-published/>Three
Key Approaches to Increasing Research Antibody Validation Defined at GBSI
Workshop<http://alttox.org/three-key-approaches-to-increasing-research-antibody-validation-defined-at-gbsi-workshop/>
Sherry Ward, AltTox Event Was Most Representative Gathering of Scientific
Experts Ever Convened on the Topic PACIFIC GROVE, Calif., September 28,
2016—Leading experts from the international biomedical research community
announced today that they have the fundamentals of what will become the first
detailed standardized guidelines for validating research antibodies. The
outcomes of this week’s Antibody […]Read
More<http://alttox.org/three-key-approaches-to-increasing-research-antibody-validation-defined-at-gbsi-workshop/>Conference:
New Frontiers in 3D Cell Culture-based Screening
Technologies<http://alttox.org/conference-new-frontiers-in-3d-cell-culture-based-screening-technologies/>
Catherine Willet, HSUS Full-day event on 3D microtissue models for more
relevant translational screening methods and safety testing October 13
Baltimore, MD, USA Advanced 3D tissue models are changing the shape of in vitro
testing for drug discovery and development from flat, monolayer cell culture to
more complex 3D systems providing greater physiological relevance. The […]Read
More<http://alttox.org/conference-new-frontiers-in-3d-cell-culture-based-screening-technologies/>BRAIN
Initiative Updates: NSF encourages researchers with expertise in data science;
Initiative seeks to include more diverse fields of
science<http://alttox.org/brain-initiative-updates-nsf-encourages-researchers-with-expertise-in-data-science-initiative-seeks-to-include-more-diverse-fields-of-science/>
Sherry Ward, AltTox NSF Announces Data Resources for the BRAIN Initiative
September 22, 2016 …NSF, a partner in the BRAIN Initiative® supporting
fundamental research across a spectrum of disciplines within neuroscience, has
released a Dear Colleague Letter (see below) encouraging researchers with
expertise in data science to partner with BRAIN Initiative projects, including
projects funded by the […]Read
More<http://alttox.org/brain-initiative-updates-nsf-encourages-researchers-with-expertise-in-data-science-initiative-seeks-to-include-more-diverse-fields-of-science/>NICEATM
Director Participates in Congressional
Briefing<http://alttox.org/niceatm-director-participates-in-congressional-briefing/>
Catherine Sprankle, NICEATM NICEATM Director Warren Casey was a panelist for a
September 13 Congressional briefing on “Alternatives to Animal Testing:
Emerging Uses and Policy Implications.” Casey and other panelists discussed how
to use non-animal and alternative toxicology and safety testing methods to
better protect consumers and public health while using fewer animals. Topics
considered […]Read
More<http://alttox.org/niceatm-director-participates-in-congressional-briefing/>Computational
Biology Symposium at NIH September
16<http://alttox.org/computational-biology-symposium-at-nih-september-16/>
Catherine Sprankle, NICEATM PLoS Computational Biology is presenting a
Computational Biology Symposium on the National Institutes of Health campus on
Friday, September 16, from 9:30 a.m.-4:00 p.m. Keynote speakers will include
Dr. David J. Lipman of the National Center for Biotechnology Information, Dr.
Jennifer Lippincott-Schwartz of the Eunice Kennedy Shriver National Institute
of Child Health […]Read
More<http://alttox.org/computational-biology-symposium-at-nih-september-16/>FDA
Seeks Comment on Draft Guidance for Toxicokinetics
Studies<http://alttox.org/fda-seeks-comment-on-draft-guidance-for-toxicokinetics-studies/>
Catherine Sprankle, NICEATM A U.S. Food and Drug Administration (FDA) notice in
the September 8 Federal Register requested comments on draft guidance titled
“ICH S3A Guidance: Note for Guidance on Toxicokinetics: The Assessment of
Systemic Exposure in Toxicity Studies—Questions and Answers.” The draft
guidance facilitates interpretation of the ‘‘S3A Guidance: The Assessment of
Systemic Exposure […]Read
More<http://alttox.org/fda-seeks-comment-on-draft-guidance-for-toxicokinetics-studies/>NICEATM
Workshop Report Recognized as an NIEHS Paper of the
Month<http://alttox.org/niceatm-workshop-report-recognized-as-an-niehs-paper-of-the-month/>
Catherine Sprankle, NICEATM The September issue of the Environmental Factor,
the newsletter of the National Institute of Environmental Health Sciences
(NIEHS), recognized the report on the Collaborative Workshop on Aquatic Models
and 21st Century Toxicology as an NIEHS Intramural Paper of the Month. The
workshop, organized by NICEATM and North Carolina State University, reviewed
emerging […]Read
More<http://alttox.org/niceatm-workshop-report-recognized-as-an-niehs-paper-of-the-month/>October
13 Webinar on GLPs and Other News from
IIVS<http://alttox.org/october-13-webinar-on-glps-and-other-news-from-iivs/>
Sherry Ward, AltTox Free IIVS Webinar on GLPs: Oct. 13, 10-11 am ET Join a
complimentary one-hour webinar, “How GLPs Enhance the Quality of Both Regulated
and Non-Regulated In Vitro Toxicology” on Thursday, Oct. 13 at 10 am ET. Led by
IIVS Director of Quality & Compliance, Amanda Ulrey, RQAP-GLP, the webinar will
introduce some […]Read
More<http://alttox.org/october-13-webinar-on-glps-and-other-news-from-iivs/>Announcement
of 2016 ARDF Alternatives Research Grant awards<http://alttox.org/6433-2/>
Sue A. Leary, ARDF The Alternatives Research & Development Foundation (ARDF) is
pleased to announce the recipients of the 2016 Alternatives Research Grants.
Luca Cucullo, PhD Texas Tech University Health Sciences Center, Amarillo, TX A
humanized blood-brain tumor barrier model to assess drug delivery of
chemotherapeutic treatment Dongeun (Dan) Huh, PhD University of Pennsylvania,
Philadelphia, […]Read More<http://alttox.org/6433-2/>Employment Opportunity:
Corporate Liaison for PETA’s Regulatory Testing
Department<http://alttox.org/employment-opportunity-corporate-liaison-petas-regulatory-testing-department/>
Katherine Groff, PETA International Science Consortium Ltd. PETA’s Regulatory
Testing Department is seeking a Corporate Liaison to join its growing team.
This person will work with major corporations to replace and reduce animal
testing. A successful candidate will attend corporate meetings and scientific
conferences and maintain expertise in nonanimal test methods and international
regulatory requirements. […]Read
More<http://alttox.org/employment-opportunity-corporate-liaison-petas-regulatory-testing-department/>CAAT
Academy: Kidney toxicity testing and best
practices<http://alttox.org/caat-academy-kidney-toxicity-testing-and-best-practices/>
Francois Busquet, CAAT Dates: September 22-23, 2016 Location: Vienna, Austria,
Evercyte Laboratories This 2-days training will give a comprehensive overview
of the most relevant and robust 2D and 3D kidney cell culture models and in
vitro applications for the assessment of kidney-associated cytotoxicity.
Webinar will be available during the training but for the presentations only.
[…]Read
More<http://alttox.org/caat-academy-kidney-toxicity-testing-and-best-practices/>Upcoming
calls for proposals<http://alttox.org/upcoming-calls-for-proposals/>
Sherry Ward, AltTox Engineering Next-Generation Human Nervous System
Microphysiological Systems (R21) (PAR-16-397) and (R01) (PAR-16-398)
Application Receipt/Submission Date(s): Standard dates apply through January 8,
2020 This Funding Opportunity Announcement (FOA) encourages research grant
applications directed toward developing next-generation human cell-derived
microphysiological systems (MPS) with improved fidelity to complex human brain,
spinal, peripheral nervous system and/or […]Read
More<http://alttox.org/upcoming-calls-for-proposals/>U.S. Strategy and Roadmap
for Implementing 21st Century Toxicity Testing
Approaches<http://alttox.org/u-s-strategy-and-roadmap-for-implementing-21st-century-toxicity-testing-approaches/>
Catherine Sprankle, NICEATM The focus of the September 27 meeting of the
Scientific Advisory Committee on Alternative Toxicological Methods (SACATM)
will be topics related to the development of a U.S. strategy and roadmap for
implementing 21st century toxicity testing approaches. Background material and
specific questions to be discussed by SACATM are included in an “In […]Read
More<http://alttox.org/u-s-strategy-and-roadmap-for-implementing-21st-century-toxicity-testing-approaches/>Funding
Opportunity for Alternative Methods
Development<http://alttox.org/funding-opportunity-for-alternative-methods-development/>
Catherine Sprankle, NICEATM The National Toxicology Program Interagency Center
for the Evaluation of Alternative Methods (NICEATM) encourages U.S. small
businesses involved in alternative methods development to apply for Small
Business Innovation Research (SBIR) Phase IIB Awards for Validation and
Commercialization of Approaches to Reduce Animal Use in Toxicology Testing
offered by the National Institute of […]Read
More<http://alttox.org/funding-opportunity-for-alternative-methods-development/>Chips
in Space: Webinar September
6<http://alttox.org/chips-in-space-webinar-september-6/>
Catherine Sprankle, NICEATM The National Center for Advancing Translational
Sciences (NCATS) and the Center for the Advancement of Science in Space are
promoting a new program for research on the International Space Station United
States National Laboratory (ISS-NL): we’re sending tissue chips to space! This
program will leverage recent advances in tissue engineering and
microfabrication […]Read
More<http://alttox.org/chips-in-space-webinar-september-6/>OECD lists newly
“endorsed” AOPS<http://alttox.org/oecd-lists-newly-endorsed-aops/>
Catherine Willet, HSUS OECD has created a new web page to list Adverse Outcome
Pathways that have undergone scientific review by experts and have been agreed
by the OECD National Coordinators to represent the current state of knowledge:
Four of the first five AOPs to have undergone this review are now posted:
Adverse Outcome Pathway […]Read
More<http://alttox.org/oecd-lists-newly-endorsed-aops/>NIH request for comments
on scope of animal-human chimera research – deadline extended to September
6<http://alttox.org/nih-request-for-comments-on-scope-of-animal-human-chimera-research-deadline-extended-to-september-6/>
Sherry Ward, AltTox “The National Institutes of Health (NIH) is requesting
public comment on a proposal to amend Section IV and Section V of the NIH
Guidelines for Human Stem Cell Research, and on the proposed scope of certain
human-animal chimera research that will be considered internally by an NIH
steering committee to provide programmatic […]Read
More<http://alttox.org/nih-request-for-comments-on-scope-of-animal-human-chimera-research-deadline-extended-to-september-6/>CRACK
IT Announces 4 New Challenges; Partners Sought for Other
Projects<http://alttox.org/crack-it-announces-4-new-challenges-partners-sought-for-other-projects/>
Sherry Ward, AltTox The 2016 CRACK IT Challenges competition consists of the
following four Challenges: Maximise: “To develop reliable predictions which
confidently classify mixtures of chemicals for acute oral toxicity, skin and
eye irritation with a focus on relevance for human safety. These should fulfill
acute GHS Classification and Labeling requirements for non-encapsulated
agrochemical mixtures […]Read
More<http://alttox.org/crack-it-announces-4-new-challenges-partners-sought-for-other-projects/>IIVS
Makes Shortlist for Prestigious LUSH Prize for its Work to Reduce Animal
Testing<http://alttox.org/iivs-makes-shortlist-for-prestigious-lush-prize-for-its-work-to-reduce-animal-testing/>
Sherry Ward, AltTox The Institute for In Vitro Sciences, Inc. (IIVS) is pleased
to be among the projects and scientists that have made the shortlist for the
2016 LUSH Prize. Awarded by LUSH, the maker of fresh handmade cosmetics, the
annual £250,000 prize recognizes achievements in the non-animal testing sector
in five main categories: Lobbying, […]Read
More<http://alttox.org/iivs-makes-shortlist-for-prestigious-lush-prize-for-its-work-to-reduce-animal-testing/>ICCVAM
2014-2015 Biennial Progress Report Now
Available<http://alttox.org/iccvam-2014-2015-biennial-progress-report-now-available/>
Catherine Sprankle, NICEATM The ICCVAM 2014-2015 Biennial Progress Report is
now available on the National Toxicology Program website. This report, prepared
in accordance with requirements of the ICCVAM Authorization Act of 2000 (42
U.S.C. 285l-3), describes ICCVAM and ICCVAM agency activities from January 2014
through December 2015. Key ICCVAM, ICCVAM agency, and NICEATM accomplishments
summarized […]Read
More<http://alttox.org/iccvam-2014-2015-biennial-progress-report-now-available/>Webinar
Series on Inhalation Toxicity Concludes September
8<http://alttox.org/webinar-series-on-inhalation-toxicity-concludes-september-8/>
Catherine Sprankle, NICEATM NICEATM and the PETA International Science
Consortium (PISC) are co-hosting a webinar series on Alternative Approaches for
Acute Inhalation Toxicity to Address Global Regulatory and Non-regulatory Data
Requirements. The last webinar in the series will be Thursday, September 8,
from 11:00 a.m. to 12:30 p.m. EDT. Dan Huh, Ph.D., University of Pennsylvania,
[…]Read
More<http://alttox.org/webinar-series-on-inhalation-toxicity-concludes-september-8/>Workshop
Report on Carcinogenicity of Mixtures Now
Available<http://alttox.org/workshop-report-on-carcinogenicity-of-mixtures-now-available/>
Catherine Sprankle, NICEATM An August 2015 workshop sponsored by the National
Institute of Environmental Health Sciences evaluated the scientific support for
the Low-Dose Mixture Hypothesis of Carcinogenesis and developed a research
agenda. A report from this workshop is now available on the Environmental
Health Perspectives website. NICEATM Deputy Director Nicole Kleinstreuer,
Ph.D., was a breakout […]Read
More<http://alttox.org/workshop-report-on-carcinogenicity-of-mixtures-now-available/>Unilever
offering annual award to promote alternatives in
China<http://alttox.org/unilever-offering-annual-award-to-promote-alternatives-in-china/>
Catherine Willet, HSUS Unilever has launched an award to promote development
and application of alternatives in China. The award called “Chinese Society of
Toxicology Toxicology Unilever Alternatives Awards” was set up by Chinese
society of toxicology, funded by Unilever. Two types of awards were announced:
“Chinese Society of Toxicology Toxicology alternatives Unilever Innovation
Award” (3 winners) and the “Chinese Society of Toxicology […]Read
More<http://alttox.org/unilever-offering-annual-award-to-promote-alternatives-in-china/>NC
Newspaper Names NICEATM Director “Tar Heel of the
Week”<http://alttox.org/nc-newspaper-names-niceatm-director-tar-heel-of-the-week/>
Catherine Sprankle, NICEATM In its Sunday, August 7, edition, The Raleigh News
and Observer named NICEATM Director Warren Casey, Ph.D., as its “Tar Heel of
the Week.” The newspaper’s weekly feature recognizes North Carolinians who have
made important contributions to their areas of interest or expertise. The
article noted that Casey, recipient of this year’s […]Read
More<http://alttox.org/nc-newspaper-names-niceatm-director-tar-heel-of-the-week/>NICEATM
Requests Information on Acute Toxicity Testing
Technologies<http://alttox.org/niceatm-requests-information-on-acute-toxicity-testing-technologies/>
Catherine Sprankle, NICEATM In a July 18 Federal Register notice, NICEATM
requested data and information on approaches and technologies currently used to
identify substances with the potential to cause acute systemic toxicity when
swallowed, inhaled, or absorbed through the skin. Respondents should provide
information on any activities relevant to the development or validation of
alternatives […]Read
More<http://alttox.org/niceatm-requests-information-on-acute-toxicity-testing-technologies/>ACI
Advancing the Science Webinar Series: Chemical-Induced
Asthma<http://alttox.org/aci-advancing-the-science-webinar-series-chemical-induced-asthma/>
Sherry Ward, AltTox There are two remaining webinars in ACI series on
Chemical-induced Asthma: August 26th 11 a.m. Eastern Time Scott Dotson (NIOSH)
– Asthma Risk Assessment: A Regulatory Perspective October 21st 11 a.m. Eastern
Time Andrew Maier (University of Cincinnati) – Asthma-specific Hazard
Characterization Approaches: A Novel Approach to a Complex ProblemRead
More<http://alttox.org/aci-advancing-the-science-webinar-series-chemical-induced-asthma/>OECD
publishes guidance document on waiving mammalian acute toxicity
tests<http://alttox.org/6339-2/>
Kate Willett, HSUS The OECD has published a Guidance Document on Considerations
for Waiving or Bridging of Mammalian Acute Toxicity Tests. From the
introduction: The OECD Guidelines for the Testing of Chemicals are continually
evolving to reflect changing assessment practices. Acute toxicity tests are an
area of focus for developing alternative assays to address animal […]Read
More<http://alttox.org/6339-2/>Beagle Freedom Prize for Non-Animal
Methods<http://alttox.org/beagle-freedom-prize-for-non-animal-methods/>
Sherry Ward, AltTox Beagle Freedom Project will award $250,000 in grants to
applicants whose goal is to replace the common use of dogs and other animals in
research, testing, and/or education with a non-animal approach. A total of five
possible awards of $50,000 are scheduled, or larger sized grants are available
to fewer awardees depending […]Read
More<http://alttox.org/beagle-freedom-prize-for-non-animal-methods/>REACH
annexes amended on use alternative
methods<http://alttox.org/reach-annexes-amended-on-use-alternative-methods/>
Sherry Ward, AltTox The European Chemicals Agency (ECHA) provides the latest
news on chemical registration obligations under REACH on their REACH 2018 web
page. “The REACH requirements for skin corrosion/irritation, serious eye
damage/eye irritation, acute dermal toxicity and skin sensitisation are
changing, making non-animal testing the default requirement.” The changes and
new requirements are explained […]Read
More<http://alttox.org/reach-annexes-amended-on-use-alternative-methods/>European
Pharmacopoeia Commission adopts revised general chapter on monocyte activation
test to facilitate reduction in animal
testing<http://alttox.org/european-pharmacopeia-commission-adopts-revised-general-chapter-on-monocyte-activation-test-to-facilitate-reduction-in-animal-testing/>
Sherry Ward, AltTox Source: https://www.edqm.eu/en/node/15240 “During its 155th ;
Session, held in Strasbourg on 21-22 June 2016, the European Pharmacopoeia
Commission adopted a revision of the general chapter Monocyte-activation test
(2.6.30) in order to make it more widely useable by stakeholders and thus
facilitate a reduction in testing on live animals.” The press release provides
additional […]Read
More<http://alttox.org/european-pharmacopeia-commission-adopts-revised-general-chapter-on-monocyte-activation-test-to-facilitate-reduction-in-animal-testing/>
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