Cross-posted with permission: The study about this was done at Purdue School of Veterinary Medicine and the distinguished Drs. Glickman are among the authors of the paper. I looked at the survival curves which show that the incidence of osteosarcoma in Rottweilers neutered before 1 year of age is 3.8 times higher than the incidence of osteosarcoma in Rottweilers that have never been neutered. Although this study pertains to Rottweilers only, my breeder's veterinarian, Dr. S. Ettinger, the famous veterinary cardiologist and editor of the textbook of internal medicine for veterinarians, feels that it might be prudent that this study should be extrapolated to pertain to giant breeds in general, as osteosarcoma is a serious threat for all these breeds. For Rottweilers spayed or neutered after 3.5 years of age, the incidence of osteosarcoma is still higher than in Rottweilers never spayed or neutered. I have given quite some thought to this study, as my breeder strongly advises against early spay/neuter. I have thought that my Newfoundland might do better in performance events if he were neutered, but obviously he cannot perform well if he is sick or if he's dead, so he remains intact and is now 3.5 years old. You can take a look at the article for yourselves at: __http://cebp.http://cebp.http://cebp.http://cebphttp://ce_ (http://cebp.aacrjournals.org/content/11/11/1434.full?eaf_) (_http://cebp.http://cebp.http://cebp.http://cebphttp://c_ (http://cebp.aacrjournals.org/content/11/11/1434.full?eaf) ) If I got this wrong, you can go to my breeder's website at www.newfoundlanddogwrong, y scroll to the bottom of the home page and click on the link to this osteosarcoma study. For me, the most interesting part is the survival curves, which you can click on and enlarge. Priscilla Hensel, M.D. Tinyurl link to the study referenced above: __http://tinyurl.http://tinyu_ (http://tinyurl.com/ykqm89l_) (_http://tinyurl.http://tiny_ (http://tinyurl.com/ykqm89l) ) _http://tinyurl.http://tiny_ (http://tinyurl.com/ykqm89l) Donna & the Dosido Gang Remlap, Alabama Visit me at _www.doublenickellife.blogspot.com_ (http://www.doublenickellife.blogspot.com/) and help support the Alabama Canine Coalition by shopping/searching through _http://www.goodsearch.com_ (http://www.goodsearch.com/) and _http://www.igive.com_ (http://www.igive.com/) Every year of dog love is worth seven years of the human stuff. (Michael Rosen)