On Monday 21 March 2011 13:12:12 Kishi wrote: > I'm using mira3 for assembly with Solexa data.... > I have over 35 million Illumina reads, 100 bp, and in the log directory > mira3 generates a very large file.... (~ 3 tera HD) You did not specify which version of MIRA and which command you used. I'm guessing here: 3.2.1 and a denovo job? This would be outside the recommended specification for MIRA 3.2.1, see http://mira-assembler.sourceforge.net/docs/DefinitiveGuideToMIRA.html#sect_for_which_data_sets_to_use_mira_and_for_which_not > How do I avoid this? Have a look at the latest development release (3.2.1.9) on SourceForge ... that one will bring a first relief. The next development version (due sometime in the next week) will improve disk utilisation even further. B.