[ascct] NIEHA-NCAT-UNC DREAM Toxicogenetics Challenge
- From: Kristie Sullivan <KSullivan@xxxxxxxx>
- To: "ascct@xxxxxxxxxxxxx" <ascct@xxxxxxxxxxxxx>
- Date: Wed, 12 Jun 2013 11:29:21 -0400
The NIEHS-NCATS-UNC DREAM Toxicogenetics Challenge
[http://www.niehs.nih.gov/funding/challenges/ ] was announced by Sage
Bionetworks
[http://sagebase.org<http://sagebase.org/><http://www.niehs.nih.gov/funding/challenges/%20]%20was%20announced%20by%20Sage%20Bionetworks%20[http://sagebase.org<http://sagebase.org/>>]
on June 11. The objective of this three-month Challenge is to build predictive
models of cytotoxicity based on data obtained from in vitro studies in which
lymphoblastoid cell lines derived from 884 individuals were exposed to 156
environmental toxicants and drugs.
This computational Challenge aims to engage diverse communities of scientists
in competitively solving one or both of two related subchallenges. In
subchallenge 1, participants are asked to model interindividual variability in
cytotoxicity based on genomic profiles in order to predict cytotoxicity in
unknown individuals. In subchallenge 2, participants are asked to predict
population-level parameters of cytotoxicity across chemicals based on
structural attributes of compounds in order to predict median cytotoxicity and
mean variance in toxicity for unknown compounds. Interested individuals can
sign up to participate.
The Challenge closes on September 15, 2013, and the top-scoring team(s) will be
announced in November 2013. The winner of each subchallenge will be invited to
speak at the 2013 DREAM conference to be held on November 8-12 in Toronto,
Canada in conjunction with the Sixth Annual RECOMB/ISCB Conference on
Regulatory and Systems Genomics.
Kristie Sullivan
Secretary, ASCCT
www.ascctox.org<http://www.ascctox.org>
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- » [ascct] NIEHA-NCAT-UNC DREAM Toxicogenetics Challenge - Kristie Sullivan
