[ascct] NIEHA-NCAT-UNC DREAM Toxicogenetics Challenge

  • From: Kristie Sullivan <KSullivan@xxxxxxxx>
  • To: "ascct@xxxxxxxxxxxxx" <ascct@xxxxxxxxxxxxx>
  • Date: Wed, 12 Jun 2013 11:29:21 -0400

The NIEHS-NCATS-UNC DREAM Toxicogenetics Challenge 
[http://www.niehs.nih.gov/funding/challenges/ ] was announced by Sage 
 on June 11. The objective of this three-month Challenge is to build predictive 
models of cytotoxicity based on data obtained from in vitro studies in which 
lymphoblastoid cell lines derived from 884 individuals were exposed to 156 
environmental toxicants and drugs.

This computational Challenge aims to engage diverse communities of scientists 
in competitively solving one or both of two related subchallenges. In 
subchallenge 1, participants are asked to model interindividual variability in 
cytotoxicity based on genomic profiles in order to predict cytotoxicity in 
unknown individuals. In subchallenge 2, participants are asked to predict 
population-level parameters of cytotoxicity across chemicals based on 
structural attributes of compounds in order to predict median cytotoxicity and 
mean variance in toxicity for unknown compounds.  Interested individuals can 
sign up to participate.

The Challenge closes on September 15, 2013, and the top-scoring team(s) will be 
announced in November 2013. The winner of each subchallenge will be invited to 
speak at the 2013 DREAM conference to be held on November 8-12 in Toronto, 
Canada in conjunction with the Sixth Annual RECOMB/ISCB Conference on 
Regulatory and Systems Genomics.

Kristie Sullivan
Secretary, ASCCT

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