Re: [statisticalgenetics] Journal club - 13/12/12
- From: Jian Yang <jian.yang@xxxxxxxxx>
- To: "statisticalgenetics@xxxxxxxxxxxxx" <statisticalgenetics@xxxxxxxxxxxxx>
- Date: Thu, 13 Dec 2012 03:52:21 +0000
For those who were there at the journal club this morning.
Correction:
=95GWAS data =96 Discovery
=96CD: 6K vs. 15K (=EB =3D 1.14)
=96Assuming K =3D 0.1%, equivalent N_QT =3D 49K
=96GIANT2 height: N =3D 120K, =EB =3D 1.4
=96Predicted =EB =3D 1.08 (h2 =3D 22% for CD and h2 =3D 44% for height)
Cheers,
Jian
From: Gibran Hemani <g.hemani@xxxxxxxxx<mailto:g.hemani@xxxxxxxxx>>
Reply-To: "statisticalgenetics@xxxxxxxxxxxxx<mailto:statisticalgenetics@fre=
elists.org>" <statisticalgenetics@xxxxxxxxxxxxx<mailto:statisticalgenetics@=
freelists.org>>
Date: Friday, 7 December 2012 5:52 PM
To: "statisticalgenetics@xxxxxxxxxxxxx<mailto:statisticalgenetics@freelists=
.org>" <statisticalgenetics@xxxxxxxxxxxxx<mailto:statisticalgenetics@freeli=
sts.org>>
Subject: [statisticalgenetics] Journal club - 13/12/12
Hi all
Next week will be the final journal club of the year, Jian Yang will be pre=
senting the following paper:
"Host=96microbe interactions have shaped the genetic architecture of inflam=
matory bowel disease"
Jostins et al
Nature 2012 491:11 119-124
Time: 10.15am Thursday 13th December
Place: 7th floor seminar room, QBI
Download it here: http://complextraitgenomics.com/journal_club/pdf/Jostins2=
012.pdf
This will be the last journal club of the year, and we'll resume again on 1=
0th January. Look forward to seeing you all again then!
All the best
Gib
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<div>For those who were there at the journal club this morning.</div>
<div><br>
</div>
<div>
<div>Correction:</div>
</div>
<div><br>
</div>
<div>=95<span style=3D"color: black; ">GWAS </span><span style=3D"color: bl=
ack; ">data =96 Discovery</span></div>
<div>
<div class=3D"O1" style=3D"margin-top:5.76pt;margin-bottom:0pt;margin-left:=
.81in;
text-indent:-.31in;text-align:left;direction:ltr;unicode-bidi:embed;mso-lin=
e-break-override:
none;word-break:normal;punctuation-wrap:hanging">
=96<span style=3D"color: black; ">CD: </span><span style=3D"color: black; "=
6K vs. 15K (</span><span style=3D"color: black; ">=EB</span><span style=3D=
"color: black; "> =3D 1.14</span><span style=3D"color: black; ">)</span></d=
iv>
<div class=3D"O1" style=3D"margin-top:5.76pt;margin-bottom:0pt;margin-left:=
.81in;
text-indent:-.31in;text-align:left;direction:ltr;unicode-bidi:embed;mso-lin=
e-break-override:
none;word-break:normal;punctuation-wrap:hanging">
=96<span style=3D"color: black; ">Assuming K =3D </span><span style=3D"colo=
r: black; ">0.1%</span><span style=3D"color: black; ">, equivalent N_QT =3D
</span><span style=3D"color: black; ">49</span><span style=3D"color: black;=
">K</span></div>
<div class=3D"O1" style=3D"margin-top:5.76pt;margin-bottom:0pt;margin-left:=
.81in;
text-indent:-.31in;text-align:left;direction:ltr;unicode-bidi:embed;mso-lin=
e-break-override:
none;word-break:normal;punctuation-wrap:hanging">
=96<span style=3D"color: black; ">GIANT2 height: N =3D 120K, </span><span s=
tyle=3D"color: black; ">=EB</span><span style=3D"color: black; "> =3D
</span><span style=3D"color: black; ">1.4</span></div>
<div class=3D"O1" style=3D"margin-top:5.76pt;margin-bottom:0pt;margin-left:=
.81in;
text-indent:-.31in;text-align:left;direction:ltr;unicode-bidi:embed;mso-lin=
e-break-override:
none;word-break:normal;punctuation-wrap:hanging">
=96<span style=3D"color: black; ">Predicted </span><span style=3D"color: bl=
ack; ">=EB</span><span style=3D"color: black; "> =3D
</span><span style=3D"color: black; ">1.08 </span><span style=3D"color: bla=
ck; ">(h</span><span style=3D"color: black; vertical-align: super; ">2</spa=
n><span style=3D"color: black; "> =3D 22% for CD and h</span><span style=3D=
"color: black; vertical-align: super; ">2</span><span style=3D"color: black=
; ">
=3D 44% for height)</span></div>
<div class=3D"O1" style=3D"margin-top:5.76pt;margin-bottom:0pt;margin-left:=
.81in;
text-indent:-.31in;text-align:left;direction:ltr;unicode-bidi:embed;mso-lin=
e-break-override:
none;word-break:normal;punctuation-wrap:hanging">
<br>
</div>
<!--EndFragment--></div>
<div>Cheers,</div>
<div>Jian</div>
<div><br>
</div>
<span id=3D"OLK_SRC_BODY_SECTION">
<div style=3D"text-align: left; color: black; border-bottom-width: medium; =
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h: medium; border-right-style: none; border-right-color: initial; padding-t=
op: 3pt; ">
<span style=3D"font-weight:bold">From: </span>Gibran Hemani <<a href=3D"=
mailto:g.hemani@xxxxxxxxx";>g.hemani@xxxxxxxxx</a>><br>
<span style=3D"font-weight:bold">Reply-To: </span>"<a href=3D"mailto:s=
tatisticalgenetics@xxxxxxxxxxxxx">statisticalgenetics@xxxxxxxxxxxxx</a>&quo=
t; <<a href=3D"mailto:statisticalgenetics@xxxxxxxxxxxxx";>statisticalgene=
tics@xxxxxxxxxxxxx</a>><br>
<span style=3D"font-weight:bold">Date: </span>Friday, 7 December 2012 5:52 =
PM<br>
<span style=3D"font-weight:bold">To: </span>"<a href=3D"mailto:statist=
icalgenetics@xxxxxxxxxxxxx">statisticalgenetics@xxxxxxxxxxxxx</a>" <=
;<a href=3D"mailto:statisticalgenetics@xxxxxxxxxxxxx";>statisticalgenetics@f=
reelists.org</a>><br>
<span style=3D"font-weight:bold">Subject: </span>[statisticalgenetics] Jour=
nal club - 13/12/12<br>
</div>
<div><br>
</div>
<div>
<div style=3D"word-wrap: break-word; -webkit-nbsp-mode: space; -webkit-line=
-break: after-white-space; ">
Hi all
<div><br>
</div>
<div>Next week will be the final journal club of the year, Jian Yang will b=
e presenting the following paper:</div>
<div><br>
</div>
<div>"Host=96microbe interactions have shaped the genetic architecture=
of inflammatory bowel disease"<br>
Jostins et al</div>
<div>Nature 2012 491:11 119-124</div>
<div><br>
</div>
<div>Time: 10.15am Thursday 13th December</div>
<div>Place: 7th floor seminar room, QBI</div>
<div><br>
</div>
<div>Download it here: <a href=3D"http://complextraitgenomics.com/jour=
nal_club/pdf/Jostins2012.pdf">http://complextraitgenomics.com/journal_club/=
pdf/Jostins2012.pdf</a></div>
<div><br>
</div>
<div>This will be the last journal club of the year, and we'll resume again=
on 10th January. Look forward to seeing you all again then!</div>
<div><br>
</div>
<div>All the best</div>
<div>Gib</div>
</div>
</div>
</span>
</body>
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</b></span><span style="font-family:'Helvetica'; font-size:medium;">13 December
2012 03:52:39 GMT<br>
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