[ SHOWGSD-L ] DM is polygenic according to top geneticist

  • From: Kathy Tank <rbuffdogs@xxxxxxxxx>
  • To: showgsd-l@xxxxxxxxxxxxx
  • Date: Thu, 24 May 2012 08:43:29 -0700

Hi Guys I am re-sending this because I got an "ecartis" (bounce)
so if you have already seen it, I apologize.
Paula according to Dr. Jerold Bell, Tufts Univ,  Geneticist, Vet, Breeder
and Exhibitor, it IS polygenic
Here is a quote from one of his articles from the AKC.

*"Degenerative myelopathy is considered a complexly (polygenic) inherited
disease. An autosomal recessive susceptibility gene has been identified
that is homozygous (two abnormal copies) in all DM affected dogs. However,
a large proportion of individuals in these breeds are homozygous for this
gene and do not become affected. They are considered ?at risk?, but not
genetically affected."*

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*Here is the link to his full article. It is a PDF, so scroll down to the
3rd set of pages,*

*the DM subject begins there.*

*http://clubs.akc.org/NBC/Bell%20Handout%20-%20NBC.pdf<http://www.facebook.com/l.php?u=http%3A%2F%2Fclubs.akc.org%2FNBC%2FBell%2520Handout%2520-%2520NBC.pdf&h=ZAQErUuD5AQFcaXdYc6pwJpJkQeXB8JEPAcDmhk--Saoxjw&enc=AZOuTWrEH42E_FWRD2_Z9HLQPfKMo4PdhyystKij6j5bB84I_DXO7Lx5UpirDQoRKZBu2MsiF-c2xSZcQKE1atPlfm94Ma9BhFM2YYD0oEJYXg>
*


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Kathy

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*"Victory...*Vires et honestas"

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