Bishop's 2002 abstract plus references. Reference 13 (Watkins et al. 2002) is of particular interest because this work links frontostriatal grey-matter abnormalities (detected trough MRI) to inherited speech and language disorders. Giancarlo Buoiano. Trends in Genetics Volume 18, Issue 2, 1 February 2002, Pages 57-59 ---------------------------------------------------------------------------- - Putting language genes in perspective Dorothy V. M. Bishop Dept of Experimental Psychology, University of Oxford, South Parks Road, Oxford, UK OX1 3UD Abstract A point mutation has recently been found in a gene from affected members of a family with an autosomal dominant pattern of inheritance for specific speech and language impairment. However, this does not mean we have localized the `gene for language'. The phenotype is complex, and the affected gene, which is concerned with regulating activity of other genes, is common to human and mouse. The discovery is nevertheless important, because it will help us to identify target genes that play a role in development of the neural circuitry involved in language. Abstract A point mutation has been found that leads to severe speech and language disorder. What are the implications for our understanding of what makes humans special? Author Keywords: specific language impairment; mutation; grammar; evolution Subject-index terms: Genetics; Evolution; Cognitive Science; Molecular Medicine; Neuroscience References 1. J.G. Hacia , Genome of the apes. Trends Genet. 17 (2001), pp. 637?645. SummaryPlus | Full Text + Links | PDF (151 K) 2. V.J. Cook and M. Newson Chomsky's Universal Grammar, Blackwell (1996). 3. S. Pinker The Language Instinct. The New Science of Language and Mind, Penguin Books (1994). 4. D.V.M. Bishop Uncommon Understanding: Development and Disorders of Language Comprehension in Children, Psychology Press (1997). 5. D.V.M. Bishop , Genetic and environmental risks for specific language impairment in children. Philos. Trans. R. Soc. London Ser. B 356 (2001), pp. 369?380. Abstract-Elsevier BIOBASE | Abstract-MEDLINE | $Order Document | Full Text via CrossRef 6. C.S.L. Lai et al., A forkhead-domain gene is mutated in a severe speech and language disorder. Nature 413 (2001), pp. 519?523. Abstract-MEDLINE | Abstract-PsycINFO | Abstract-GEOBASE | Abstract-EMBASE | Abstract-BIOTECHNOBASE | Abstract-Elsevier BIOBASE | $Order Document | Full Text via CrossRef 7. C. Lai et al., The SPCH1 region on human 7q31: genomic characterization of the critical interval and localization of translocations associated with speech and language disorder. Am. J. Hum. Genet. 67 (2000), pp. 357?368. Abstract-BIOTECHNOBASE | Abstract-MEDLINE | Abstract-EMBASE | Abstract-Elsevier BIOBASE | $Order Document | Full Text via CrossRef 8. M. Gopnik , Some evidence for impaired grammars. In: R. Jackendoff and P. Bloom, Editors, Language, Logic and Concepts. Essays In Memory of John Macnamara, MIT Press/Bradford (1999), pp. 263?283. Abstract-PsycINFO | $Order Document 9. Watkins, K.E. et al. Behavioural analysis of an inherited speech and language disorder: comparison with acquired aphasia. Brain (in press). 10. D.V.M. Bishop et al., The relationship between phoneme discrimination, speech production and language comprehension in cerebral-palsied individuals. J. Speech Hear. Res. 33 (1990), pp. 210?219. Abstract-MEDLINE | Abstract-PsycINFO | Abstract-EMBASE | $Order Document 11. C.F. Norbury et al., Production of verb morphology. A comparison of SLI and moderate hearing impairment. J. Speech Lang. Hear. Res. 44 (2001), pp. 165?178. Abstract-MEDLINE | Abstract-PsycINFO | $Order Document 12. S. Pääbo , Human evolution. Trends Genet. 15 (1999), pp. M13?M16. SummaryPlus | Full Text + Links | PDF (359 K) SummaryPlus | Full Text + Links | PDF (359 K) SummaryPlus | Full Text + Links | PDF (359 K) 13. Watkins, K.E. et al. MRI analysis of an inherited speech and language disorder: structural brain abnormalities. Brain (in press). 14. The SLI Consortium. A genome-wide scan identifies two novel loci involved in specific language impairment (SLI). Am. J. Hum. Genet. (in press). ---------------------------------------------------------------------------- - Trends in Genetics Volume 18, Issue 2, 1 February 2002, Pages 57-59