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SPORTS MEDICINE :
PHYSICAL EXERCISE AND FITNESS :
MEDICAL: DISEASES: CORONARY ARTERY DISEASE, MULTIPLE SCLEROSIS:
Aerobic Exercise Reduces Risk of Coronary Artery Disease
in People With Mild / Moderate MS
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Aerobic Exercise Reduces Risk of Coronary Artery Disease
in People With Mild / Moderate MS
APS Contact: Donna Krupa
The American Physiological Society Press Release
http://www.the-aps.org/mm/hp/Audiences/Public-Press/Archive/07/24.html
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WASHINGTON Multiple sclerosis (MS) is a degenerative disease affecting
the central nervous system of 400,000 Americans with 200 more diagnosed
each week. The disease causes reduced nerve function and consequently a
variety of symptoms. The most commonly reported symptoms include muscle
weakness, spasticity, excess fatigue and depression, which often results
in a vicious cycle of reduced mobility and decreased physical activity.
Reduced activity level predisposes people with MS to be at increased risk
for secondary diseases such as diabetes, osteoporosis and coronary artery
disease (CAD).
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In an effort to improve the health status of those with MS, a team of
researchers worked with individuals diagnosed with mild to moderate
disability in an eight week aerobic cycling regimen. The investigators
found that people with MS improved their aerobic fitness and reduced their
level of CAD risk.
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These findings are drawn from a study entitled Aerobic Exercise Influence
on Coronary Artery Disease Risk Factors in Multiple Sclerosis. It was
conducted by Darpan Patel, Vanessa Castellano, Sean McCoy, Ashley Blazina
and Lesley White, all of the University of Florida, Department of Applied
Physiology and Kinesiology, Gainesville, FL. Patel will present the teams
findings at the 120th annual meeting of the American Physiological Society
(APS; www.The-APS.org), being held as part of the Experimental Biology
conference (EB 07). More than 12,000 scientific researchers will attend
the gathering being held April 28-May 2, 2007 at the Washington, DC
Convention Center.
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The Study: Summary of Methodology
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Eleven MS patients and 11 matched controls (age, sex, body mass index)
participated in the study. MS patients were clinically stable and had mild
to moderate disability. All volunteers (MS and control subjects) had
physician clearance and met specific inclusion/exclusion criteria.
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Once enrolled, subjects participated in an eight week supervised aerobic
cycling exercise protocol wherein they exercised three days per week.
Each exercise session consisted of a three minute warm up at a
self-assessed comfortable speed followed by 30 minutes of cycle ergometry
(continuous or intermitant) at 60 percent of VO2peak, consistent with the
American College of Sports Medicine (ACSM) guidelines for improving health
and fitness.
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snip
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Discussion/Conclusions
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The results of this study support earlier work done by this research team,
which showed exercise was associated with reduced individual CAD risk
factors among resistance trained MS subjects. The results suggest that
people with mild to moderate MS are capable of improving their aerobic
fitness to levels similar to their non-MS counterparts. Thus, while
physical inactivity may predispose MS patients to have increased CAD risk,
MS-related symptoms do not preclude this group from potentially reducing
their risk factors through exercise.
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