[net-gold] PROTEINS : COMPUTER GAMES AND GAMING: Fold Proteins, Help Cure Diseases in Foldit Video Game
- From: "David P. Dillard" <jwne@xxxxxxxxxx>
- To: Net-Gold <Net-Gold@xxxxxxxxxxxxxxx>, Temple University Net-Gold Archive <net-gold@xxxxxxxxxxxxxxxxxxx>, Temple Gold Discussion Group <TEMPLE-GOLD@xxxxxxxxxxxxxxxxxxx>, Net-Gold <net-gold@xxxxxxxxxxxxxxxx>, Sean Grigsby <myarchives1@xxxxxxxxxxxxxxx>, Educator Gold <Educator-Gold@xxxxxxxxxxxxxxx>, Educator Gold <Educator-Gold@xxxxxxxxxxxxxxxx>, K12AdminLIFE <K12AdminLIFE@xxxxxxxxxxxxxxx>, Net-Platinum <net-platinum@xxxxxxxxxxxxxxx>, NetGold <netgold@xxxxxxxxxxxxxxx>, "Net-Gold @ Nabble" <ml-node+3172864-337556105@xxxxxxxxxxxxx>, K-12ADMINLIFE <K12ADMIN@xxxxxxxxxxxxxxxxxxx>, net-gold@xxxxxxxxxxxxx, MediaMentor <mediamentor@xxxxxxxxxxxxxxx>, Digital Divide Diversity MLS <mls-digitaldivide@xxxxxxxxxxxxxxx>
- Date: Thu, 5 Aug 2010 15:49:16 -0400 (EDT)
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PROTEINS :
COMPUTER GAMES AND GAMING:
Fold Proteins, Help Cure Diseases in Foldit Video Game
Fold Proteins, Help Cure Diseases in Foldit Video Game
Matt Peckham
PC World
Aug 5, 2010 7:11 am
<http://www.pcworld.com/article/202617/
fold_proteins_help_cure_diseases_in_foldit_video_game.html>
A shorter URL for the above link:
<http://tinyurl.com/27sxbtt>
Leave it to video gamers to find a better way to shepherd proteins into
their optimal three-dimensional shapes.
Plying a freely available game and matched against automated computer
routines designed to ascertain how amino acids twist into their ideal
shapes, science journal Nature reports video gamers took top marks,
folding proteins better than a computer.
<snip>
"People in the scientific community have known about Foldit for a while,
and everybody thought it was a great idea," wrote UW associate computer
science and engineer professor Zoran Popovic in a press statement. "But
the really fundamental question in most scientists' minds was 'What can it
produce in terms of results? Is there any evidence that it's doing
something useful?"
"I hope this paper will convince a lot of those people who were sitting on
the sidelines, and the whole genre of scientific discovery games will
really take off."
Why protein folding? Because protein feeds your muscles and helps ferry
signals in your brain that control your body, and because improper
folding, which can produce inactive or incorrectly folded proteins, is
associated with everything from allergies to several neurodegenerative
diseases. Understanding how proteins ought to fold helps researchers
predict and target protein structures with
In a Video Game, Tackling the Complexities of Protein Folding
By JOHN MARKOFF
Published: August 4, 2010
New York Times
<http://www.nytimes.com/2010/08/05/science/05protein.html>
The success of the Foldit players, the researchers report in this weeks
issue of Nature, shows that nonscientists can collaborate to develop new
strategies and algorithms that are distinct from traditional software
solutions to the challenge of protein folding.
The researchers took pains to credit the volunteers who competed at Foldit
in the last two years, listing Foldit players at the end of the reports
author list and noting that more than 57,000 players contributed
extensively through their feedback and gameplay.
Zoran Popovic, a computer scientist at the University of Washington who
was a lead author of the paper, said, If things go according to plan, not
too long from now, such massive author lists should be commonplace. Foldit
begins with a series of tutorials in which the player controls proteinlike
structures on a computer display. In the game, as structures are modified,
a score is calculated based on how well the protein is folded. Players are
given a set of controls that let them do things like shake, wiggle and
rebuild to reshape the backbone and the amino acid side shapes of a
specific protein into a more efficient structure.
A list of top scores for each puzzle is posted so that players can compare
their results. Players may also collaborate in teams, tracking progress on
a separate list of group scores.
The protein-folding problem can be solved by computers using statistical
and related software algorithms, but it takes an immense amount of
processing power.
Letter
Nature 466, 756-760 (5 August 2010) | doi:10.1038/nature09304; Received 22
January 2010; Accepted 30 June 2010
Predicting protein structures with a multiplayer online game
Seth Cooper1, Firas Khatib2, Adrien Treuille1,3, Janos Barbero1, Jeehyung
Lee3, Michael Beenen1, Andrew Leaver-Fay2,5, David Baker2,4, Zoran
Popovic1 & Foldit players
The complete articles may be read at the URLs provided for each.
Sincerely,
David Dillard
Temple University
(215) 204 - 4584
jwne@xxxxxxxxxx
<http://daviddillard.businesscard2.com>
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