[net-gold] New Test Announced for Early Detection of Asbestos Related Lung Cancer
- From: "David P. Dillard" <jwne@xxxxxxxxxx>
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- Date: Wed, 6 Apr 2011 12:12:31 -0400 (EDT)
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Date: Tue, 05 Apr 2011 20:37:48 -0000
From: JonG <jon@xxxxxxxxxxx>
Reply-To: Net-Gold@xxxxxxxxxxxxxxx
To: Net-Gold@xxxxxxxxxxxxxxx
Subject: [Net-Gold] New Test Announced for Early Detection of Asbestos Related
Lung Cancer
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New Test Announced for Early Detection
of Asbestos Related Lung Cancer
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Researchers at NYU Langone Medical
Center have investigated a novel
protein test to detect early-stage,
asbestos-related pulmonary cancer.
The test can accurately identify
proteins secreted from cancerous
tumors caused by asbestos exposure.
The study was presented at the
American Association for Cancer
Research 102nd Annual Meeting 2011
on April 4th.
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In a blinded test performed under
the sponsorship of the National
Cancer Institute's Early Detection
Research Network Biomarker Discovery
Lab, researchers detected 15 of 19
cases of stage 1 or stage 2 malignant
pleural mesothelioma. The study shows
the test is approximately 80 percent
sensitive in identifying disease.
In addition, the specificity of the
test was 100 percent with no false
positives.
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Malignant pleural mesothelioma is an
aggressive, asbestos-related pulmonary
cancer that develops in the lining of
the lungs. Each year, the disease
causes an estimated 15,000 to 20,000
deaths worldwide. It can be fatal
within 14 months following diagnosis
because of the advanced stage that it
is typically found.
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The goal of a new diagnostic test is
to find the cancer early enough to
effectively treat it, according to
Harvey I. Pass, MD, director of the
Division of Thoracic Surgery and
Thoracic Oncology at NYU Langone
Medical Center and the NYU Cancer
Institute.
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"The only patients that seem to benefit
from therapy in mesothelioma are those
that are found in stage 1, and this is
only 10 to 15 percent of patients,"
said lead researcher Dr. Pass.
"Moreover, when found early, the
magnitude of the operation necessary to
reduce the burden of disease may be less,
making the patient better able to cope
if the disease recurs and the patient
needs more aggressive therapy."
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The research team used the "Multiplex
SOMAmer Assay" by SomaLogic, Inc. to
examine 170 blood samples from 90
patients diagnosed with malignant
mesothelioma and 80 participants who
were previously exposed to asbestos.
The technology uses SOMAmers,
chemically modified single-stranded
DNA molecules to bind specifically to
target proteins , to identify and
quantify biomarkers.
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According to Dr. Pass, this test
measures 19 protein biomarkers for
malignant pleural mesothelioma and is
able to find and quantify the small
amount of proteins secreted by tumor
cells. Ongoing studies are refining
the test and validating the results
in other patient blood samples.
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Complete Article With Links:
http://tinyurl.com/4y8sebx
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