[net-gold] MEDICAL: DISEASES : HEALTH : VITAMINS: Vitamin D Found to Influence Over 200 Genes, Highlighting Links to Disease
- From: "David P. Dillard" <jwne@xxxxxxxxxx>
- To: Net-Gold -- Educator Gold <Educator-Gold@xxxxxxxxxxxxxxx>, Educator Gold <Educator-Gold@xxxxxxxxxxxxxxxx>, net-gold@xxxxxxxxxxxxx, Net-Gold <Net-Gold@xxxxxxxxxxxxxxx>, NetGold <netgold@xxxxxxxxxxxxxxx>, Net-Gold <net-gold@xxxxxxxxxxxxxxxx>, K-12ADMINLIFE <K12ADMIN@xxxxxxxxxxxxxxxxxxx>, K12AdminLIFE <K12AdminLIFE@xxxxxxxxxxxxxxx>, MediaMentor <mediamentor@xxxxxxxxxxxxxxx>, Digital Divide Diversity MLS <mls-digitaldivide@xxxxxxxxxxxxxxx>, NetGold <netgold@xxxxxxxxxxxxxxxx>, Net-Platinum <net-platinum@xxxxxxxxxxxxxxx>, Sean Grigsby <myarchives1@xxxxxxxxxxxxxxx>, Temple Gold Discussion Group <TEMPLE-GOLD@xxxxxxxxxxxxxxxxxxx>, Temple University Net-Gold Archive <net-gold@xxxxxxxxxxxxxxxxxxx>, Health Lists -- Health Diet Fitness Recreation Sports Tourism <healthrecsport@xxxxxxxxxxxxxxxx>, Health Diet Fitness Recreation Sports <healthrecsport@xxxxxxxxxxxxxxx>, HEALTH-RECREATION-SPORTS-TOURISM@xxxxxxxxxxxxxxxxxxx, Sport-Med <SPORT-MED@xxxxxxxxxxxxxx>, sport-med@xxxxxxxxxxxxxxxx, sports-med@xxxxxxxxxxxxxxx, sport-med@xxxxxxxxxxxxxxxxxxx
- Date: Tue, 24 Aug 2010 07:58:10 -0400 (EDT)
.
MEDICAL: DISEASES :
HEALTH :
VITAMINS:
Vitamin D Found to Influence Over 200 Genes,
Highlighting Links to Disease
Vitamin D Found to Influence Over 200 Genes,
Highlighting Links to Disease
Science News
<http://www.sciencedaily.com/releases/2010/08/100823172327.htm>
ScienceDaily (Aug. 23, 2010) The extent to which vitamin D deficiency may
increase susceptibility to a wide range of diseases is dramatically
highlighted in newly published research. Scientists have mapped the points
at which vitamin D interacts with our DNA -- and identified over two
hundred genes that it directly influences.
The results are published in the journal Genome Research.
It is estimated that one billion people worldwide do not have sufficient
vitamin D. This deficiency is thought to be largely due to insufficient
exposure to the sun and in some cases to poor diet. As well as being a
well-known risk factor for rickets, there is a growing body of evidence
that vitamin D deficiency also increases an individual's susceptibility to
autoimmune conditions such as multiple sclerosis (MS), rheumatoid
arthritis and type 1 diabetes, as well as certain cancers and even
dementia.
Now, in a study whose funders include the Medical Research Council (MRC),
the MS Society, the Wellcome Trust and the MS Society of Canada,
researchers at the University of Oxford have shown the extent to which
vitamin D interacts with our DNA. They used new DNA sequencing technology
to create a map of vitamin D receptor binding across the genome. The
vitamin D receptor is a protein activated by vitamin D, which attaches
itself to DNA and thus influences what proteins are made from our genetic
code.
The complete article may be read at the URL above.
A ChIP-seq defined genome-wide map of vitamin D receptor binding:
Associations with disease and evolution
Sreeram V. Ramagopalan, Andreas Heger, Antonio J. Berlanga, Narelle J.
Maugeri, Matthew R. Lincoln, Amy Burrell, Lahiru Handunnetthi, Adam E.
Handel, Giulio Disanto, Sarah-Michelle Orton, Corey T. Watson, Julia M.
Morahan, Gavin Giovannoni, Chris P. Ponting, George C. Ebers, and Julian
C. Knight
Genome Res. Published in Advance August 24, 2010,
doi:10.1101/gr.107920.110
...ChIP-seq defined genome-wide map of vitamin D receptor binding:
Associations with...vitamin D, through its cognate nuclear vitamin D
receptor (VDR), and its contribution...changes in expression in response
to vitamin D. VDR binding sites were significantly...
<http://genome.cshlp.org/content/early/2010/08/20/
gr.107920.110.full.pdf+html?sid=f96395e1-6f5a-4e14-9549-e58585890055>
A shorter URL for the above link:
<http://tinyurl.com/23gh97g>
Sincerely,
David Dillard
Temple University
(215) 204 - 4584
jwne@xxxxxxxxxx
<http://daviddillard.businesscard2.com>
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