[net-gold] MEDICAL: CONDITIONS: ALZHEIMER'S: Alzheimer Test Developed Largely at Penn Proves Effective
- From: "David P. Dillard" <jwne@xxxxxxxxxx>
- To: Net-Gold <Net-Gold@xxxxxxxxxxxxxxx>, Temple University Net-Gold Archive <net-gold@xxxxxxxxxxxxxxxxxxx>, Temple Gold Discussion Group <TEMPLE-GOLD@xxxxxxxxxxxxxxxxxxx>, Net-Gold <net-gold@xxxxxxxxxxxxxxxx>, Sean Grigsby <myarchives1@xxxxxxxxxxxxxxx>, Educator Gold <Educator-Gold@xxxxxxxxxxxxxxx>, Educator Gold <Educator-Gold@xxxxxxxxxxxxxxxx>, K12AdminLIFE <K12AdminLIFE@xxxxxxxxxxxxxxx>, Net-Platinum <net-platinum@xxxxxxxxxxxxxxx>, NetGold <netgold@xxxxxxxxxxxxxxx>, K-12ADMINLIFE <K12ADMIN@xxxxxxxxxxxxxxxxxxx>, MediaMentor <mediamentor@xxxxxxxxxxxxxxx>, Digital Divide Diversity MLS <mls-digitaldivide@xxxxxxxxxxxxxxx>, net-gold@xxxxxxxxxxxxx, NetGold <netgold@xxxxxxxxxxxxxxxx>
- Date: Wed, 11 Aug 2010 08:50:46 -0400 (EDT)
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MEDICAL: CONDITIONS: ALZHEIMER'S:
Alzheimer Test Developed Largely at Penn Proves Effective
Alzheimer Test Developed Largely at Penn Proves Effective
Posted on Wed, Aug. 11, 2010
By Faye Flam
Inquirer Staff Writer
Philadelphia Inquirer
<http://www.philly.com/inquirer/health_science/daily/
20100811_Alzheimer_test_developed_largely_at_Penn_proves_effective.html>
A shorter URL for the above link:
<http://tinyurl.com/252pv4l>
A screening test developed largely at the University of Pennsylvania has
proved surprisingly good at predicting who will go from relatively mild
memory decline to full-blown Alzheimer's disease.
Scientists are just starting to use this test to identify people at a much
earlier stage in the disease and get them into clinical trials of drugs
being developed to combat Alzheimer's.
And that's raising hopes that new drugs might fight the disease early,
before the brain becomes irreparably damaged, said John Trojanowski, a
Penn neuropathologist who helped develop the test - a measure of three
proteins in patients' cerebrospinal fluid. Another Penn researcher, Leslie
Shaw, also played a lead role in developing the test.
In Trojanowski's vision, doctors may eventually be able to screen for
pre-Alzheimer's disease and treat it with drugs the same way they can
screen patients for high blood pressure or cholesterol and prevent heart
attacks and strokes.
A paper published yesterday in the Archives of Neurology compiled a number
of different studies of the test, which requires a lumbar puncture.
The test measures relative concentrations of two key proteins, both of
them connected with the abnormal brain deposits that characterize the
disease. What separates the positive from negative results is a telltale
pattern - an Alzheimer's signature.
One of the more striking results came from a study of 57 people who were
initially diagnosed with what's called mild cognitive dementia - a decline
in memory and thinking that can be clearly measured by doctors - and then
went on to develop Alzheimer's disease within five years.
All of those people had shown an "Alzheimer's signature" on the test
before they developed the full-blown disease, Trojanowski said.
---------------------------------------
The complete article may be read at the URL above.
Diagnosis-Independent Alzheimer Disease Biomarker Signature in Cognitively
Normal Elderly People
Geert De Meyer, PhD; Fred Shapiro, MLS; Hugo Vanderstichele, PhD; Eugeen
Vanmechelen, PhD; Sebastiaan Engelborghs, MD, PhD; Peter Paul De Deyn, MD,
PhD; Els Coart, PhD; Oskar Hansson, MD; Lennart Minthon, MD; Henrik
Zetterberg, MD, PhD; Kaj Blennow, MD, PhD; Leslie Shaw, PhD; John Q.
Trojanowski, MD, PhD; for the Alzheimer's Disease Neuroimaging Initiative
Arch Neurol. 2010;67(8):949-956. doi:10.1001/archneurol.2010.179
<http://archneur.ama-assn.org/cgi/content/short/67/8/949>
Conclusions The mixture modeling approach, totally independent of
clinical AD diagnosis, correctly classified patients with AD. The
unexpected presence of the AD signature in more than one-third of
cognitively normal subjects suggests that AD pathology is active and
detectable earlier than has heretofore been envisioned.
Group Information: A list of the Alzheimer's Disease Neuroimaging
Initiative members appears at
http://www.adni-info.org/ISAB/ISABMembers.aspx.
Sincerely,
David Dillard
Temple University
(215) 204 - 4584
jwne@xxxxxxxxxx
<http://daviddillard.businesscard2.com>
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