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INFANTS : INFANCY : NEWBORNS : EARLY CHIIDHOOD :
MEDICAL: INFECTIONS :
MEDICAL: DISEASES: OBESITY:
Infection, Not Antibiotic Use, Linked to Childhood Obesity Risk
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Infection, Not Antibiotic Use, Linked to Childhood Obesity Risk
Li DK, et al. Lancet Diabetes Endocrinol. 2016
doi:10.1016/s2213-8587(16)30281-9.
November 11, 2016
Regina Schaffer
Healio
http://www.healio.com/endocrinology/obesity/news/in-the-journals/
%7B2633dea1-eeed-48bf-80ee-6d92f79def19%7D/infection-
not-antibiotic-use-linked-to-childhood-obesity-risk
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A shorter URL for the above link:
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http://tinyurl.com/jhhmph6
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Infection without antibiotic use in infancy is associated with an
increased risk for childhood obesity, whereas both broad- and
narrow-spectrum antibiotics were not associated with an increased obesity
risk, according to findings from a longitudinal birth cohort study.
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To isolate the effect of antibiotic use, we compared antibiotic users with
those who had similar underlying infection diagnostic codes but who did
not use antibiotics, De-Kun Li, MD, senior research scientist at the
Kaiser Foundation Research Institute at Kaiser Permanente Northern
California, and colleagues wrote. We used several analytical methods,
including propensity score, and our findings showed that once underlying
infection types and severity are controlled for, exposure to antibiotics
in infancy overall is not associated with an increased risk of childhood
obesity, whereas infection during infancy was associated with an increased
risk. The association between infection and childhood obesity was further
supported by a clear doseresponse relation.
.
snip
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While there are many other reasons for deciding whether antibiotics should
be used, in the context of preventing childhood obesity, treating infant
infections with antibiotics is not likely to increase childhood obesity,
Li told Endocrine Today. In fact, not treating infections in infancy could
increase the risk of childhood obesity that you are worried about.
Regina Schaffer
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The complete article may be read at the URL above.
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Infection and antibiotic use in infancy and risk of childhood obesity: a
longitudinal birth cohort study
Dr Prof De-Kun Li, MDcorrespondencePress enter key for correspondence
informationemailPress enter key to Email the author, Hong Chen, MPH,
Jeannette Ferber, MPH, Roxana Odouli, MSPH
Published: 01 November 2016
Article has an altmetric score of 274
DOI: http://dx.doi.org/10.1016/S2213-8587(16)30281-9
Lancet
http://www.thelancet.com/pdfs/journals/
landia/PIIS2213-8587(16)30281-9.pdf
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A shorter URL for the above link:
.
http://tinyurl.com/god5bxm
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Summary
Background
Data from previous studies have suggested a possible association between
antibiotic use in infancy and risk of childhood obesity, with implications
for health-care delivery and obesity prevention strategies. However,
whether the observed association was due to antibiotic use or underlying
infection, or both, is unclear. We aimed to disentangle the effect of
antibiotic use in infancy from that of underlying infection on the risk of
childhood obesity.
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snip
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Interpretation
Infection, but not antibiotic use, during infancy is associated with risk
of childhood obesity. This finding will need to be replicated in future
studies. Although our results do not rule out a potential effect of
antibiotics on microbiome composition and the use of antibiotics should
always be judicious, they suggest that treatment of common infections with
antibiotics in infancy is unlikely to be a main contributor to childhood
obesity.
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Additional Reading
Forrest, Christopher B., Jason P. Block, and L. Charles Bailey.
"Antibiotics, infections, and childhood obesity."
The Lancet Diabetes & Endocrinology (2016).
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