http://www.truth-out.org/news/item/39556-researchers-find-pesticide-spills-accidents-may-alter-farmworkers-dna
[links in on-line article]
Researchers Find Pesticide Spills, Accidents May Alter Farmworkers' DNA
Wednesday, February 22, 2017
By Brian Bienkowski, Environmental Health News | Report
Farmworkers who have a high pesticide exposure event -- such as a spill
-- are more likely to experience molecular changes on DNA that may lead
to certain cancers, according to a large US study of pesticide
applicators in Iowa and North Carolina.
The research, part of the ongoing Agricultural Health Study that is
monitoring the health of more than 57,000 private and commercial
pesticide applicators in Iowa and North Carolina, adds to growing
evidence that high exposure to certain pesticides may spur prostate and
other cancers in people handling the chemicals.
"This lines up perfectly with what the National Cancer Institute is
doing on the markers that increase the risk of cancer. It's a timely,
relevant study," said Linda McCauley, dean and professor of Emory
University's Nell Hodgson Woodruff School of Nursing. McCauley was not
involved in the study.
Researchers have long suspected pesticides may play a role in the
elevated cancer rates among farmers and others who apply pesticides.
Using data from the same Agricultural Health Study group, in 2003
researchers reported about a 14 percent higher prostate cancer incidence
than the general population of men in Iowa and North Carolina. The
fumigant methyl bromide was most strongly associated with prostate
cancer. Use of chlorinated pesticides, such as DDT, was linked to cancer
for applicators over 50 years old.
Then, in 2013, using the same study group, researchers found that men
exposed to certain pesticides -- fonofos (taken off the market in 1998),
terbufos and malathion -- were more likely to develop aggressive forms
of prostate cancer.
The current study, published last month in the journal "Environmental
and Molecular Mutagensis," sought to provide evidence on how pesticides
might promote cancer. It included 596 male pesticide applicators. Men
who experienced a "high pesticide exposure event," meaning a spill or
other accident that would leave them highly exposed, were more likely to
have elevated levels of DNA methylation in a gene linked with increased
prostate cancer risk.
This type of exposure to pesticides would be "unusually high," said lead
author Dr. Jennifer Rusiecki, an assistant professor of medicine at
Uniformed Services University in Maryland.
Proper DNA methylation controls a number of important processes in our
body, including regulating how genes are expressed. Certain genes,
including ones examined in this study, commonly have elevated DNA
methylation during certain cancers.
Almost a quarter of the men surveyed reported a high pesticide exposure
event in their past. It's not entirely clear how the pesticides may
induce these DNA changes. Rusiecki said it could be through oxidative
stress, a molecular change that can damage DNA known as alkylation, or
disruption of the body's hormones.
The new study was limited in that the high pesticide exposure was
self-reported and wasn't specific to any particular pesticides, Rusiecki
said, so it's unclear what the applicators were exposed to.
Farming carries other risk factors beyond pesticides as well. There are
other exposures -- gasoline and diesel emissions, solvents, dusts, oils
and microbes -- that are higher than the average person. Family history
plays an important role in men's susceptibility to prostate cancer as well.
However the study bolsters what many researchers suspect, McCauley said.
"Our entire pesticide regulatory system is built on neurotoxicity and
poisonings," she said. But many chemicals that don't necessarily prove
acutely toxic can inconspicuously harm the body over time.
"There are changes that happen to the body before we kill the body,"
said McCauley, who helps communicate pesticide research to migrant
farmworkers. "It's really sad how [farmworkers] are told 'don't worry,
there's not a problem,' when they know that working around these
chemicals cannot be healthy for them."
Personal protection equipment is not enough to protect farmworkers
health, said Nishelle Harriott, science and regulatory director of
Beyond Pesticides, which advocates for phasing out harmful pesticides.
"Long sleeve shirts, gloves are considered personal protective
equipment," she said. "Those things wouldn't do much for someone
breathing these chemicals in."
"Big Setback"
Harriott's organization and many others have long pushed for the
phase-out of harmful pesticides, but the new Trump Administration may
make their job difficult.
The president has repeatedly talked about reducing government
interference and regulation. His appointee for Secretary of Agriculture,
Georgia governor Sonny Perdue, has been an advocate of pesticides in the
past and voted to get rid of laws targeting agricultural pollution in
his state.
Trump's pick to run the US Environmental Protection Agency, which
regulates and registers pesticides, is Oklahoma Attorney General Scott
Pruitt, who has made a career fighting the agency over its regulation of
pollution.
The US Centers for Disease Control and Prevention found that Pruitt's
home state leads the nation in pesticides deaths and illnesses,
according to analysis of data from 2000 to 2010.
The EPA is currently reviewing a number of controversial pesticides,
including glyphosate, atrazine and neonicotinoids. In the most immediate
case, the agency has until March 31 to rule on Dow AgroSciences'
chlorpyrifos, a chemical widely used on a variety of crops such as corn,
asparagus, broccoli and soybeans. The agency's risk assessments found
the chemical is not safe.
Over the past two decades many environmental groups have asked for a ban
over concerns regarding impacts to children's development.
The new administration is a "big setback," said Emily Marquez, a staff
scientist at the Pesticide Action Network.
"We have to make sure we're sticking up for people threatened by any
policies that might affect people like pesticide applicators, or people
that live near farms that use pesticides."