Dear colleagues and dear friends The desire to transition to animal-free systemic toxicity testing is fueled by testing needs such as the European REACH regulation and a possible US TSCA reauthorization as well as testing bans for cosmetic ingredients in Europe. Other areas and novel products could similarly benefit from human predictive approaches. A recent stocktaking (Adler et al. 2011) and its expert review (Hartung et al. 2011) identified gaps in the science available. In order to promote the development of a roadmap to close these gaps, an expert workshop was held (Basketter et al 2012), which shall be presented and discussed here in a multi-stakeholder forum. Please note that the participation in this event is free of charge, and that due to the limited number of participants a registration is required. For registration please contact caat-eu@xxxxxxxxxxxxxxx Best, Thomas Hartung & Marcel Leist CAAT-Europe, CAAT-US, CEFIC, Cosmetics Europe, DZF, ECOPA, ESTIV, EUSAAT, IIVS, IVTIP, HSI and ToxCast Center for Alternatives to Animal Testing-Europe University of Konstanz POB 600 78457 Konstanz Germany Phone: 0049-7531-882233 Fax: 0049-7531-884156